CRK and MICAL1

Number of citations of the paper that reports this interaction (PMID 11827972)
28

Data Source:
BioGRID (pull down)

		CRK	MICAL1
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog	microtubule associated monooxygenase, calponin and LIM domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Intermediate Filament
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding	Actin Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Rab GTPase Binding FAD Binding
	Biological Process	Activation Of MAPKK Activity Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Insulin Receptor Signaling Pathway Platelet Activation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Oxidation-reduction Process
Pathways		Signalling to ERKs Prolonged ERK activation events Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by Insulin receptor Innate Immune System Signaling by PDGF Signalling by NGF Insulin receptor signalling cascade p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane ARMS-mediated activation Signaling by Interleukins Signal attenuation Signaling by VEGF Downstream signal transduction Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		84 interactors: ABL1 ABL2 ARHGAP17 ARHGAP32 ASAP1 ATXN1 AVIL BCAR1 BCR BUB1 CBL CBLC CRKL DAB1 DOCK1 DOCK3 DOK1 DOK4 DPPA4 EFS EGFR EPHA3 EPHB2 EPHB3 EPHB6 EPS15 ERBB2 ERBB3 ERBB4 FAM154A FASLG FGFR1 FLT1 FRS2 FYN GAB1 GRB2 IGF1R INSR IRS1 IRS2 IRS4 KDR KHDRBS1 KIT MAP4K1 MAP4K5 MAPK4 MAPK8 MICAL1 NCK1 NEDD9 NTRK1 PDGFRA PDGFRB PIK3R1 PLSCR1 POT1 PPFIBP2 PPP1CA PSMC6 PTK2 PTK2B PTPN1 PTPN4 PXN RAPGEF1 REPS1 RET SH3BP1 SHB SHC1 SOCS1 SOS1 SPRR2A STAT5A STAT5B SYN1 TERF2IP VAV1 WASF1 WEE1 XPO1 ZAP70	16 interactors: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		1398	64780
HPRD ID		01267	06183
Ensembl ID		ENSG00000167193	ENSG00000135596
Uniprot IDs		L7RT18 P46108	Q8TDZ2
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ	1WYL 2CO8 2DK9
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Signal Transduction Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Response To Growth Factor Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Catalytic Activity Protein Autophosphorylation Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Stimulus Cellular Response To Organonitrogen Compound Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Organic Substance Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of MAPK Cascade Immune System Process Positive Regulation Of Transferase Activity Phosphorylation Cellular Response To Peptide Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response	Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Regulation Of Phosphorylation Signal Transduction Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Signaling Cell Morphogenesis Involved In Differentiation Cell Communication Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Kinase Activity Neuron Projection Development Positive Regulation Of Protein Metabolic Process Axonogenesis Cell Development Cellular Response To Peptide Hormone Stimulus Axon Development Cellular Response To Growth Factor Stimulus Response To Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Growth Factor Neuron Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vesicle-mediated Transport Neuron Projection Morphogenesis Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Generation Of Neurons Positive Regulation Of Protein Phosphorylation Neuron Differentiation Blood Coagulation Cellular Response To Insulin Stimulus Hemostasis Regulation Of Protein Kinase Activity Ras Protein Signal Transduction Cell Projection Organization Neurogenesis Response To Peptide Hormone
Tagcloud ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Difference) ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Intersection) ?