BCAR1 and SH2D3C

Number of citations of the paper that reports this interaction (PMID 10692442)
19

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		BCAR1	SH2D3C
Gene Name		breast cancer anti-estrogen resistance 1	SH2 domain containing 3C
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Cytoplasm Membrane
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	9 interactors: BCAR1 CARD11 EFS EPHB2 MAPK1 NEDD9 PTK2B SNCAIP SRC
Entrez ID		9564	10044
HPRD ID		04248	05284
Ensembl ID		ENSG00000050820	ENSG00000095370
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	B4DG32 E7EUN5 Q8N5H7
PDB IDs		1WYX 3T6G	3T6G
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Adhesion Actin Filament Bundle Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport T Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Signal Complex Assembly Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epithelial Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Body Fluid Levels Signal Transduction Regulation Of Cell Migration Locomotion Platelet Activation Chemotaxis Actin Cytoskeleton Organization Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Immune Response Actin Filament-based Process Bone Resorption Neurotrophin Signaling Pathway Signaling Regulation Of Locomotion Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Component Movement Cell Communication Cell Proliferation B Cell Receptor Signaling Pathway
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2
Tagcloud (Intersection) ?