BCAR1 and PTPRH

Number of citations of the paper that reports this interaction (PubMedID 11278335)
0

Data Source:
HPRD (in vitro, in vivo)

		BCAR1	PTPRH
Description		BCAR1 scaffold protein, Cas family member	protein tyrosine phosphatase receptor type H
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cell Projection Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Nuclear Speck Microvillus Membrane Cell Projection
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway	Protein Dephosphorylation Apoptotic Process Signal Transduction Axon Guidance
Pathways		Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 25086665 29422604) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)	Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469)
Interacting Genes		65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EEIG1 EFS ESR1 FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ	16 interacting genes: BCAR1 CNKSR1 CRK DHPS DOK1 EGFR ERBB3 ERBB4 GHR KRTAP10-3 KRTAP10-8 LCK MAPK1 MLH1 PTK2 PXN
Entrez ID		9564	5794
HPRD ID		04248	03942
Ensembl ID		ENSG00000050820	ENSG00000080031
Uniprot IDs		B3KWE2 P56945	Q9HD43
PDB IDs		1WYX 3T6G 5O2M 5O2P 5O2Q	7XC0
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Cell Migration Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Signal Transduction Cell Motility Regulation Of Cell-substrate Adhesion Ephrin Receptor Signaling Pathway Anchoring Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Regulation Of Immune System Process Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Regulation Of Cell Motility Antigen Receptor-mediated Signaling Pathway SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Migration Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell-matrix Adhesion Intracellular Signal Transduction Cytosol Regulation Of Cytoskeleton Organization Cytoplasm Regulation Of Signal Transduction Cell Adhesion Cell-cell Junction Regulation Of Cell Junction Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Phosphatase Binding SH2 Domain Binding Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activator Activity Signal Transduction Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Macrophage Proliferation Response To Growth Factor Phosphotyrosine Residue Binding Cell Migration Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Kinase Activity Response To Epidermal Growth Factor B Cell Receptor Signaling Pathway Signal Complex Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Cell Motility Receptor Complex Basal Plasma Membrane Immune Response-regulating Signaling Pathway Focal Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of Phosphorylation Response To Hepatocyte Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Schwann Cell Development Positive Regulation Of Cell Migration T Cell Receptor Signaling Pathway
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