CRK and FER

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CRK	FER
Description		CRK proto-oncogene, adaptor protein	FER tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Neuromuscular Junction Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Lamellipodium Cell Junction Protein-containing Complex Cell Projection Anchoring Junction
	Molecular Function	Phosphotyrosine Residue Binding Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Kinase Activity Transferase Activity
	Biological Process	Neuron Migration Response To Yeast Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Population Proliferation Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Response To Hydrogen Peroxide Regulation Of GTPase Activity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Regulation Of Wound Healing Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Protein Localization To Membrane Postsynaptic Specialization Assembly Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Peptide Regulation Of Intracellular Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Regulation Of Cell Motility Negative Regulation Of Cell Motility Regulation Of T Cell Migration	Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Signal Transduction Tyrosine Phosphorylation Of STAT Protein Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Male Gonad Development Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Involved In Immune Response Adherens Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Interleukin-6-mediated Signaling Pathway Seminiferous Tubule Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Adherens Junction Disassembly Positive Regulation Of Supramolecular Fiber Organization
Pathways		ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis	Signaling by SCF-KIT
Drugs			Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 28135244 30578418)	Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) White blood cell count ( 32888494)
Interacting Genes		189 interacting genes: ABL1 ABL2 ADGRL3 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BICRA BUB1 C1orf94 C4orf17 C6orf141 CBL CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOCK5 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FAM110B FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INPP5D INSR IQCE IRS1 IRS2 IRS4 ISL1 IVL KCNJ3 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 KMT2E LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NPM3 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRR14 PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN22 PTPN4 PTPRH PTTG1 PXN RAB2B RAD54L2 RAPGEF1 REPS1 RET RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2B1 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPATA31F1 SPEN SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 SYNGAP1 TASOR2 TCAP TCOF1 TDG TERF2IP TM4SF19 TP53BP2 TRIM25 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 VPS37B WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN5 ZKSCAN7 ZNF557 ZNF804A	19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB
Entrez ID		1398	2241
HPRD ID		01267	01491
Ensembl ID		ENSG00000167193	ENSG00000151422
Uniprot IDs		A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108	P16591 Q6PEJ9
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV	2KK6 6KC4
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Cell Migration Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Protein Binding Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Insulin Receptor Signaling Pathway Cytosol Protein Phosphorylation Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cytoplasm Protein Autophosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Signaling Regulation Of Cell Communication Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Motility Regulation Of Cell Adhesion	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol ErbB-3 Class Receptor Binding Cell Motility Response To Indole-3-methanol Catenin Complex Cadherin Binding Phosphotyrosine Residue Binding Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Cell Migration Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus ERBB3:ERBB2 Complex Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling ERBB Signaling Pathway Regulation Of Angiogenesis Regulation Of Cellular Localization Regulation Of Vasculature Development ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Catenin-TCF7L2 Complex Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Localization To Nucleus Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Signaling Receptor Binding Glial Cell Differentiation Negative Regulation Of Programmed Cell Death Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Developmental Process Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Regulation Of Multicellular Organismal Process
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