CRK and VPS37B

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		CRK	VPS37B
Description		CRK proto-oncogene, adaptor protein	VPS37B subunit of ESCRT-I
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Neuromuscular Junction Protein-containing Complex Extracellular Exosome	ESCRT I Complex Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Neuron Migration Response To Yeast Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Population Proliferation Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Response To Hydrogen Peroxide Regulation Of GTPase Activity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Regulation Of Wound Healing Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Protein Localization To Membrane Postsynaptic Specialization Assembly Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Peptide Regulation Of Intracellular Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Regulation Of Cell Motility Negative Regulation Of Cell Motility Regulation Of T Cell Migration	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Viral Release From Host Cell Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 28135244 30578418)	A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		189 interacting genes: ABL1 ABL2 ADGRL3 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BICRA BUB1 C1orf94 C4orf17 C6orf141 CBL CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOCK5 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FAM110B FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INPP5D INSR IQCE IRS1 IRS2 IRS4 ISL1 IVL KCNJ3 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 KMT2E LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NPM3 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRR14 PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN22 PTPN4 PTPRH PTTG1 PXN RAB2B RAD54L2 RAPGEF1 REPS1 RET RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2B1 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPATA31F1 SPEN SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 SYNGAP1 TASOR2 TCAP TCOF1 TDG TERF2IP TM4SF19 TP53BP2 TRIM25 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 VPS37B WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN5 ZKSCAN7 ZNF557 ZNF804A	27 interacting genes: BAG3 BYSL CDC73 CRK DCUN1D1 ENKD1 ERCC1 EXOC8 FBF1 GORASP2 HGS KDM1A LNX1 NCK2 OSTF1 PRKAA1 PRKAA2 QARS1 SH3YL1 SMARCD1 SORBS3 TLE5 TSG101 UBASH3A UBASH3B UBC VPS28
Entrez ID		1398	79720
HPRD ID		01267	07794
Ensembl ID		ENSG00000167193	ENSG00000139722
Uniprot IDs		A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108	Q9H9H4
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV	6VME
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Cell Migration Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Protein Binding Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Insulin Receptor Signaling Pathway Cytosol Protein Phosphorylation Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cytoplasm Protein Autophosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Signaling Regulation Of Cell Communication Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Motility Regulation Of Cell Adhesion	Organelle Assembly Protein Localization To Vacuole Membrane Fission Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Autophagy Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Protein Localization To Lipid Droplet Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Negative Regulation Of Signal Transduction Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Localization Organelle Organization Positive Regulation Of Protein Localization Regulation Of Tubulin Deacetylation Regulation Of Protein Modification Process Lipid Droplet Disassembly Multivesicular Body Sorting Pathway Cytoplasm Protein Localization To Lysosome Phosphatidylethanolamine Biosynthetic Process Ciliary Basal Body Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Establishment Of Protein Localization To Vacuole ESCRT I Complex Regulation Of Cellular Component Organization Protein-containing Complex Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Exosomal Secretion Regulation Of Signal Transduction Fatty Acid Homeostasis Hepatocyte Apoptotic Process Regulation Of Organelle Organization Cellular Response To Prostaglandin E Stimulus Regulation Of Exosomal Secretion Cellular Component Assembly Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process
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