CRK and IFT140

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		CRK	IFT140
Description		CRK proto-oncogene, adaptor protein	intraflagellar transport 140
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Membrane Neuromuscular Junction Protein-containing Complex Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytoskeleton Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium Cone Photoreceptor Outer Segment
	Molecular Function	Phosphotyrosine Residue Binding Signaling Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Enzyme Binding Kinase Binding Protein Domain Specific Binding Signaling Receptor Complex Adaptor Activity Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding	Protein Binding
	Biological Process	Neuron Migration Response To Yeast Regulation Of Leukocyte Migration Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cell Population Proliferation Regulation Of Cell Shape Regulation Of Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Helper T Cell Diapedesis Response To Hepatocyte Growth Factor Reelin-mediated Signaling Pathway Response To Hydrogen Peroxide Regulation Of GTPase Activity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Regulation Of Dendrite Development Cell Chemotaxis Regulation Of Wound Healing Negative Regulation Of Wound Healing Response To Cholecystokinin Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Nitric Oxide Protein Localization To Membrane Postsynaptic Specialization Assembly Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Peptide Regulation Of Intracellular Signal Transduction Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Endothelin Regulation Of Cell Motility Negative Regulation Of Cell Motility Regulation Of T Cell Migration	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Cell Projection Organization Embryonic Camera-type Eye Development Limb Morphogenesis Intraciliary Retrograde Transport Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways		ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis	Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Granulocyte count ( 27863252) Intraocular pressure ( 30591961) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 28135244 30578418)	Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		189 interacting genes: ABL1 ABL2 ADGRL3 ANKZF1 ANLN AR ARHGAP17 ARHGAP32 ASAP1 ASAP3 ASCL4 ATF3 ATXN1 AVIL BATF3 BCAR1 BCR BEX5 BICRA BUB1 C1orf94 C4orf17 C6orf141 CBL CBLC CHTF18 CLNK CNDP2 CORO6 CRKL DAB1 DOCK1 DOCK3 DOCK5 DOK1 DOK2 DOK3 DOK4 DOK7 DPPA4 EFS EGFR ELK1 ELK3 EPHA3 EPHB2 EPHB3 EPHB6 EPS15 EPYC ERBB2 ERBB3 ERBB4 ESD EYA3 FAM110B FASLG FER FGFR1 FLACC1 FLT1 FRS2 FSTL1 FYN GAB1 GABPB2 GAREM1 GRB2 HABP4 HSH2D IFT140 IGF1R IKZF3 INO80E INPP5D INSR IQCE IRS1 IRS2 IRS4 ISL1 IVL KCNJ3 KCTD13 KCTD17 KDR KHDRBS1 KIT KLF15 KLHL20 KMT2E LASP1 LHX8 LNX2 MAGEC3 MAP4K1 MAP4K5 MAPK4 MAPK8 MET MICAL1 MNDA MPG MYLIP MYOZ2 NCK1 NEDD9 NPM3 NTRK1 NUFIP2 OFCC1 PAFAH1B2 PDGFRA PDGFRB PHC2 PIK3R1 PIK3R2 PIK3R3 PLSCR1 POT1 PPFIBP2 PPP1CA PRKACA PRR14 PRRC2B PRRG2 PSMC1 PSMC6 PTK2 PTK2B PTPN1 PTPN22 PTPN4 PTPRH PTTG1 PXN RAB2B RAD54L2 RAPGEF1 REPS1 RET RTCB RYBP SASH1 SAXO1 SEMA4D SEPTIN6 SETD9 SH2B1 SH2D2A SH3BP1 SHB SHC1 SOCS1 SOCS6 SOS1 SPATA31F1 SPEN SPRR2A STAT4 STAT5A STAT5B STRN4 SYN1 SYNGAP1 TASOR2 TCAP TCOF1 TDG TERF2IP TM4SF19 TP53BP2 TRIM25 TUBA1C TWIST2 TXK USP53 VAC14 VAV1 VPS37B WASF1 WDR83 WEE1 XPO1 ZAP70 ZKSCAN5 ZKSCAN7 ZNF557 ZNF804A	5 interacting genes: CELSR3 CRK NEK2 PFDN1 RANBP2
Entrez ID		1398	9742
HPRD ID		01267	11093
Ensembl ID		ENSG00000167193	ENSG00000187535
Uniprot IDs		A0A0S2Z3K9 A0A0S2Z3Q4 L7RT18 P46108	Q96RY7
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ 2MS4 5UL6 6ATV	8BBF 8BBG 8FGW 8FH3
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Cell Migration Phosphotyrosine Residue Binding Regulation Of Intracellular Signal Transduction Protein Binding Cell Motility Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Insulin Receptor Signaling Pathway Cytosol Protein Phosphorylation Response To Growth Factor Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cytoplasm Protein Autophosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Signaling Regulation Of Cell Communication Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Motility Regulation Of Cell Adhesion	Protein Folding Negative Regulation Of Innate Immune Response Protein Localization To Membrane Unfolded Protein Binding Protein-containing Complex Binding Molecular Adaptor Activity Negative Regulation Of Immune Response Localization Within Membrane Helper T Cell Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Negative Regulation Of Defense Response Neuromuscular Junction Response To Cholecystokinin Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Negative Regulation Of Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Intercellular Bridge Cytoplasmic Periphery Of The Nuclear Pore Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Type III Interferon Production Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cleavage Furrow 'de Novo' Cotranslational Protein Folding TTT Hsp90 Cochaperone Complex Translational Attenuation
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