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CRK and KDR
Number of citations of the paper that reports this interaction (PubMedID
23397142
)
45
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro)
CRK
KDR
Description
CRK proto-oncogene, adaptor protein
kinase insert domain receptor
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Neuromuscular Junction
Protein-containing Complex
Extracellular Exosome
Extracellular Region
Nucleus
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Receptor Complex
Membrane Raft
Anchoring Junction
Cell Periphery
Sorting Endosome
Molecular Function
Phosphotyrosine Residue Binding
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Biological Process
Neuron Migration
Response To Yeast
Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Protein Localization To Membrane
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Peptide
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Angiogenesis
Ovarian Follicle Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Positive Regulation Of Mesenchymal Cell Proliferation
Epithelial Cell Maturation
Endocardium Development
Endothelium Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Mesenchymal Cell Proliferation
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Lung Development
Positive Regulation Of Cell Migration
Positive Regulation Of BMP Signaling Pathway
Embryonic Hemopoiesis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Surfactant Homeostasis
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Post-embryonic Camera-type Eye Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Mitochondrial Depolarization
Calcium Ion Homeostasis
Epithelial Tube Morphogenesis
Blood Vessel Endothelial Cell Differentiation
Vascular Wound Healing
Positive Regulation Of ERK1 And ERK2 Cascade
Semaphorin-plexin Signaling Pathway
Stem Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Bone Development
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of Vasculogenesis
Pathways
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
Linifanib
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Tivozanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Olinvacimab
Diseases
GWAS
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
27841878
28135244
30578418
)
Blood protein levels (
30072576
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
189 interacting genes:
ABL1
ABL2
ADGRL3
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BICRA
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOCK5
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FAM110B
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INPP5D
INSR
IQCE
IRS1
IRS2
IRS4
ISL1
IVL
KCNJ3
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
KMT2E
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NPM3
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRR14
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN22
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAD54L2
RAPGEF1
REPS1
RET
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2B1
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPATA31F1
SPEN
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
SYNGAP1
TASOR2
TCAP
TCOF1
TDG
TERF2IP
TM4SF19
TP53BP2
TRIM25
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
VPS37B
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN5
ZKSCAN7
ZNF557
ZNF804A
63 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
KPNA4
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SNCA
SRC
STAT1
STYX
SYNGAP1
TIMP3
USP7
VEGFA
VEGFC
VEGFD
YES1
Entrez ID
1398
3791
HPRD ID
01267
01867
Ensembl ID
ENSG00000167193
ENSG00000128052
Uniprot IDs
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
P35968
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Cell Migration
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Protein Binding
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Insulin Receptor Signaling Pathway
Cytosol
Protein Phosphorylation
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
ERBB Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Cytoplasm
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Motility
Regulation Of Cell Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Anatomical Structure Formation Involved In Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Ephrin Receptor Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Angiogenesis
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of MAPK Cascade
Regulation Of Angiogenesis
Cytoplasm
Regulation Of Vasculature Development
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor 2 Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Regulation Of Programmed Cell Death
Response To Platelet-derived Growth Factor
T Cell Costimulation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Cell Motility
SH3 Domain Binding
Developmental Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Cytosol
Ephrin Receptor Signaling Pathway
Focal Adhesion
Immune Response-activating Signaling Pathway
Protein Dephosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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