BCAR1 and FES

Number of citations of the paper that reports this interaction (PMID 8999909)
9

Data Source:
HPRD (in vivo)

		BCAR1	FES
Gene Name		breast cancer anti-estrogen resistance 1	FES proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway	Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ	31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		9564	2242
HPRD ID		04248	01814
Ensembl ID		ENSG00000050820	ENSG00000182511
Uniprot IDs		B2RBL9 B3KWE2 F5H855 P56945	P07332
PDB IDs		1WYX 3T6G	1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion
Tagcloud ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?