CRK and MAPK4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRK	MAPK4
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog	mitogen-activated protein kinase 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding	MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Activation Of MAPKK Activity Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Insulin Receptor Signaling Pathway Platelet Activation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway	MAPK Cascade Protein Phosphorylation Cell Cycle
Pathways		Signalling to ERKs Prolonged ERK activation events Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by Insulin receptor Innate Immune System Signaling by PDGF Signalling by NGF Insulin receptor signalling cascade p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane ARMS-mediated activation Signaling by Interleukins Signal attenuation Signaling by VEGF Downstream signal transduction Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		84 interactors: ABL1 ABL2 ARHGAP17 ARHGAP32 ASAP1 ATXN1 AVIL BCAR1 BCR BUB1 CBL CBLC CRKL DAB1 DOCK1 DOCK3 DOK1 DOK4 DPPA4 EFS EGFR EPHA3 EPHB2 EPHB3 EPHB6 EPS15 ERBB2 ERBB3 ERBB4 FAM154A FASLG FGFR1 FLT1 FRS2 FYN GAB1 GRB2 IGF1R INSR IRS1 IRS2 IRS4 KDR KHDRBS1 KIT MAP4K1 MAP4K5 MAPK4 MAPK8 MICAL1 NCK1 NEDD9 NTRK1 PDGFRA PDGFRB PIK3R1 PLSCR1 POT1 PPFIBP2 PPP1CA PSMC6 PTK2 PTK2B PTPN1 PTPN4 PXN RAPGEF1 REPS1 RET SH3BP1 SHB SHC1 SOCS1 SOS1 SPRR2A STAT5A STAT5B SYN1 TERF2IP VAV1 WASF1 WEE1 XPO1 ZAP70	7 interactors: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5 UBC
Entrez ID		1398	5596
HPRD ID		01267	01497
Ensembl ID		ENSG00000167193	ENSG00000141639
Uniprot IDs		L7RT18 P46108	A1A4C4 P31152 Q0VG04
PDB IDs		1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Signal Transduction Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Response To Growth Factor Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Catalytic Activity Protein Autophosphorylation Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Stimulus Cellular Response To Organonitrogen Compound Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Organic Substance Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of MAPK Cascade Immune System Process Positive Regulation Of Transferase Activity Phosphorylation Cellular Response To Peptide Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activation Of MAPK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Immune System Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Immune Response Signal Transduction Regulation Of Immune System Process Defense Response Signaling JNK Cascade Regulation Of Signaling Cell Communication Cellular Response To Growth Factor Stimulus
Tagcloud ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Difference) ?		abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Intersection) ?