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CRK and KIT
Number of citations of the paper that reports this interaction (PubMedID
24728074
)
77
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
CRK
KIT
Description
CRK proto-oncogene, adaptor protein
KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Neuromuscular Junction
Protein-containing Complex
Extracellular Exosome
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Cytoplasm
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Molecular Function
Phosphotyrosine Residue Binding
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Neuron Migration
Response To Yeast
Regulation Of Leukocyte Migration
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cell Migration
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Positive Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Regulation Of Wound Healing
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Protein Localization To Membrane
Postsynaptic Specialization Assembly
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Response To Peptide
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Chemotaxis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Spermatid Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Gonad Development
Visual Learning
Male Gonad Development
Response To Radiation
Positive Regulation Of Gene Expression
Programmed Cell Death
Cell Migration
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Actin Cytoskeleton Organization
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Mast Cell Cytokine Production
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Tongue Development
Leukocyte Activation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Developmental Pigmentation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Regulation Of Developmental Process
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Reproductive Process
Pathways
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Transcriptional and post-translational regulation of MITF-M expression and activity
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
Linifanib
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Diseases
Acute myeloid leukemia (AML)
Piebaldism
GWAS
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
27841878
28135244
30578418
)
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
28017375
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
28017375
29403010
28453575
)
Mean corpuscular volume (
28453575
28017375
20139978
29403010
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
31928498
32203549
)
Interacting Genes
189 interacting genes:
ABL1
ABL2
ADGRL3
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BICRA
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOCK5
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FAM110B
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INPP5D
INSR
IQCE
IRS1
IRS2
IRS4
ISL1
IVL
KCNJ3
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
KMT2E
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NPM3
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRR14
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN22
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAD54L2
RAPGEF1
REPS1
RET
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2B1
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPATA31F1
SPEN
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
SYNGAP1
TASOR2
TCAP
TCOF1
TDG
TERF2IP
TM4SF19
TP53BP2
TRIM25
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
VPS37B
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN5
ZKSCAN7
ZNF557
ZNF804A
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
Entrez ID
1398
3815
HPRD ID
01267
01287
Ensembl ID
ENSG00000167193
ENSG00000157404
Uniprot IDs
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
A0A0U2N547
A0A8I5KQZ6
A0A8I5KS03
A0A8I5QKL5
A0A8I5QKP7
A0A8J8Z860
P10721
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
1PKG
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
7KHG
7KHJ
7KHK
7ZW8
7ZY6
8DFM
8DFP
8DFQ
8PQ9
8PQA
8PQB
8PQC
8PQD
8PQE
8PQF
8PQG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
SH3 Domain Binding
Peptidyl-tyrosine Phosphorylation
Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Cell Migration
Phosphotyrosine Residue Binding
Regulation Of Intracellular Signal Transduction
Protein Binding
Cell Motility
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Kinase Activity
Insulin Receptor Signaling Pathway
Cytosol
Protein Phosphorylation
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
ERBB Signaling Pathway
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Cytoplasm
Protein Autophosphorylation
Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Cell Migration
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Motility
Regulation Of Cell Adhesion
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cell Activation
Cell Activation
Leukocyte Activation
Regulation Of Signal Transduction
Immune System Process
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Cytosol
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Activation Of Immune Response
Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Plasma Membrane
Receptor Tyrosine Kinase Binding
Negative Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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