COL7A1 and MMP2

Number of citations of the paper that reports this interaction (PMID 10652000)
7

Data Source:
HPRD (in vivo)

		COL7A1	MMP2
Gene Name		collagen, type VII, alpha 1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways		Collagen formation Laminin interactions Collagen degradation Anchoring fibril formation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MMP2 SHKBP1 THBS1 ZC3H7A	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		1294	4313
HPRD ID		00358	00386
Ensembl ID		ENSG00000114270	ENSG00000087245
Uniprot IDs		Q02388 Q59F16	P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Blood Vessel Development Vasculature Development Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Blood Vessel Morphogenesis Locomotion Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Endodermal Cell Differentiation Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Retinal Blood Vessel Morphogenesis Cell Junction Assembly Endoderm Formation Cellular Response To Amino Acid Stimulus Developmental Process Collagen Catabolic Process Organ Morphogenesis Intramembranous Ossification Collagen Metabolic Process Cell Morphogenesis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Skeletal System Morphogenesis Bone Trabecula Formation Endoderm Development Multicellular Organismal Metabolic Process Multicellular Organismal Development Cell Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Hemidesmosome Assembly Response To Amino Acid Bone Trabecula Morphogenesis Axon Guidance Formation Of Primary Germ Layer System Development Cell Projection Morphogenesis Cell Part Morphogenesis Retina Vasculature Development In Camera-type Eye Morphogenesis Of A Polarized Epithelium Cellular Response To Acid Chemical Branching Involved In Salivary Gland Morphogenesis Gastrulation Platelet Activation	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?			5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?			5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?