MMP2 and CXCL12

Number of citations of the paper that reports this interaction (PMID 11571304)
118

Data Source:
HPRD (in vitro)

		MMP2	CXCL12
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	chemokine (C-X-C motif) ligand 12
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Extracellular Region Extracellular Space External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Receptor Binding Chemokine Activity Growth Factor Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Chemotaxis Immune Response Cell Adhesion Signal Transduction G-protein Coupled Receptor Signaling Pathway Germ Cell Development Blood Circulation Motor Neuron Axon Guidance Regulation Of Actin Polymerization Or Depolymerization Adult Locomotory Behavior Germ Cell Migration Response To Radiation Response To Heat Response To Mechanical Stimulus Response To Virus Telencephalon Cell Migration Organ Regeneration Positive Regulation Of Dopamine Secretion T Cell Proliferation Response To Peptide Hormone Positive Regulation Of Cell Adhesion Positive Regulation Of Axon Extension Involved In Axon Guidance Induction Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Myoblast Fusion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signaling by ERBB4 GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Nuclear signaling by ERBB4 Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Marimastat Captopril SC-74020	Tinzaparin
Diseases
GWAS			Coronary heart disease ( 17634449 21378990) Myocardial infarction (early onset) ( 19198609) Schizophrenia ( 23212062)
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	10 interactors: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FN1 MMP2 PF4 VCAN
Entrez ID		4313	6387
HPRD ID		00386	02904
Ensembl ID		ENSG00000087245	ENSG00000107562
Uniprot IDs		P08253	H7BYN8 P48061
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU	1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2NWG 2SDF 3GV3 3HP3 4LMQ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Locomotion Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Movement Of Cell Or Subcellular Component Cell Migration Positive Regulation Of Immune System Process Cell Motility Leukocyte Migration Response To Stress Immune System Process Regulation Of Immune System Process Cell Activation Defense Response Response To Other Organism Killing By Host Of Symbiont Cells Response To Biotic Stimulus Inflammatory Response Response To External Stimulus Regulation Of Chemotaxis Response To Bacterium Neutrophil Mediated Immunity Cell Adhesion Killing Of Cells Of Other Organism Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Positive Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Endodermal Cell Differentiation Response To Fungus Entry Into Host Cell T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Intracellular Signal Transduction Response To Hypoxia Response To Lipopolysaccharide Leukocyte Cell-cell Adhesion Endoderm Formation Regulation Of Immune Response Cardiovascular System Development Homotypic Cell-cell Adhesion Angiogenesis Response To Molecule Of Bacterial Origin Chemokine-mediated Signaling Pathway Collagen Catabolic Process
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	adam23 adenomatous apc bc bcs cumulative detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Intersection) ?