MMP2 and LGALS3

Number of citations of the paper that reports this interaction (PubMedID 7947821)
0

Data Source:
HPRD (in vitro)

		MMP2	LGALS3
Description		matrix metallopeptidase 2	galectin 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix	Immunological Synapse Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity Chemoattractant Activity Laminin Binding Disaccharide Binding Oligosaccharide Binding Molecular Condensate Scaffold Activity Receptor Ligand Inhibitor Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Immune System Process Monocyte Chemotaxis MRNA Processing RNA Splicing Cell Differentiation Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Killing Of Cells Of Another Organism Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis NK T Cell Activation Negative Regulation Of NK T Cell Activation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin	2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose
Diseases		Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Leukoderma in response to rhododendrol ( 32558222) Protein biomarker ( 23056639) Testicular germ cell tumor ( 28604728)
Interacting Genes		40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	32 interacting genes: ANXA1 APP C1GALT1C1 CRX CSNK1A1 CSNK2A1 CSNK2A2 CUBN ELN FCGR2A GEMIN4 GOLGA2 INCA1 KIF16B LGALS3BP LIM2 LINC00632 MCAM MCPH1 MEFV MMP2 MYOC PPIG PRR13 SNCA SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6 ZFTRAF1
Entrez ID		4313	3958
HPRD ID		00386	01090
Ensembl ID		ENSG00000087245	ENSG00000131981
Uniprot IDs		P08253	A0A024R693 P17931
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8ITX 8ITZ 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN 8RMT 8RMU 8RMV 8RR7 8RR8 8RR9 8RRA 8RRB 8RRC 8RRE 8RRF 8RRG 8S67 8YMD 8Z1S 8Z1T 8Z25 8ZUV
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis	Regulation Of Autophagy Positive Regulation Of Autophagy Protein Kinase CK2 Complex Positive Regulation Of Catabolic Process Negative Regulation Of Catabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Defense Response Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Response To Interleukin-1 Regulation Of Proteolysis Protein Tetramerization Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Ubiquitin Protein Ligase Activity Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Defense Response Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Response To Other Organism Vesicle-mediated Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Identical Protein Binding Negative Regulation Of Autophagy Regulation Of Receptor Recycling
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