MMP2 and COL18A1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		MMP2	COL18A1
Description		matrix metallopeptidase 2	collagen type XVIII alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Skeletal System Development Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Response To Hydrostatic Pressure
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases		Choriocarcinoma Penile cancer Torg-Winchester syndrome	Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)	Ankle injury ( 28957384) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Cardiorespiratory fitness (800m run time) ( 32572135) Early-onset Parkinson's disease ( 28256260) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 22745009) Left–right brain asymmetry ( 33723403) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)
Interacting Genes		40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	19 interacting genes: APP BGN COL1A1 COL4A1 COL6A1 CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 ITGAV ITGB1 KDR LAMA1 MMP2 SPARC TGM2 THBS1
Entrez ID		4313	80781
HPRD ID		00386	00382
Ensembl ID		ENSG00000087245	ENSG00000182871
Uniprot IDs		P08253	A0AAG2UW65 A0AAG2UXZ5 P39060
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78	1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis	Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Binding Fibronectin Binding Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Integrin Binding Developmental Process Cellular Response To Amino Acid Stimulus Angiogenesis Endodermal Cell Differentiation External Side Of Plasma Membrane Regulation Of Cell-substrate Adhesion Response To Amino Acid Cellular Developmental Process Platelet-derived Growth Factor Binding Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Signal Transduction Coreceptor Activity Wound Healing, Spreading Of Epidermal Cells Collagen Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Motility Animal Organ Development Platelet Alpha Granule Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Regulation Of Angiogenesis Laminin Binding Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Response To Activity Fibroblast Growth Factor Binding Regulation Of Developmental Process Response To Mechanical Stimulus Cell Adhesion Cell Surface Receptor Signaling Pathway
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