COL7A1 and BMP1

Number of citations of the paper that reports this interaction (PMID 11986329)
21

Data Source:
HPRD (in vivo)

		COL7A1	BMP1
Gene Name		collagen, type VII, alpha 1	bone morphogenetic protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development
Pathways		Collagen formation Laminin interactions Collagen degradation Anchoring fibril formation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		14 interactors: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MMP2 SHKBP1 THBS1 ZC3H7A	14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		1294	649
HPRD ID		00358	00209
Ensembl ID		ENSG00000114270	ENSG00000168487
Uniprot IDs		Q02388 Q59F16	P13497
PDB IDs			3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Blood Vessel Development Vasculature Development Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Blood Vessel Morphogenesis Locomotion Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Endodermal Cell Differentiation Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Retinal Blood Vessel Morphogenesis Cell Junction Assembly Endoderm Formation Cellular Response To Amino Acid Stimulus Developmental Process Collagen Catabolic Process Organ Morphogenesis Intramembranous Ossification Collagen Metabolic Process Cell Morphogenesis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Skeletal System Morphogenesis Bone Trabecula Formation Endoderm Development Multicellular Organismal Metabolic Process Multicellular Organismal Development Cell Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Hemidesmosome Assembly Response To Amino Acid Bone Trabecula Morphogenesis Axon Guidance Formation Of Primary Germ Layer System Development Cell Projection Morphogenesis Cell Part Morphogenesis Retina Vasculature Development In Camera-type Eye Morphogenesis Of A Polarized Epithelium Cellular Response To Acid Chemical Branching Involved In Salivary Gland Morphogenesis Gastrulation Platelet Activation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus
Tagcloud ?			augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Difference) ?			augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Intersection) ?