MMP2 and SPOCK1

Number of citations of the paper that reports this interaction (PubMedID 12810672)
0

Data Source:
HPRD (in vitro)

		MMP2	SPOCK1
Description		matrix metallopeptidase 2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Postsynaptic Density Sarcoplasm Extracellular Matrix Neuromuscular Junction Node Of Ranvier
	Molecular Function	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Regulation Of Cell Growth Neuron Migration Cell Adhesion Nervous System Development Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Neurogenesis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases		Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)	Body mass index ( 28552196) Bronchopulmonary dysplasia ( 23897914) HIV-1 susceptibility ( 25786224) Mathematical ability ( 28155865) Metabolite levels ( 23823483) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to quetiapine in schizophrenia ( 29503163) Weight ( 28552196)
Interacting Genes		40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	6 interacting genes: BCL2L13 CREB3L1 MMP14 MMP2 MMP3 UBC
Entrez ID		4313	6695
HPRD ID		00386	11887
Ensembl ID		ENSG00000087245	ENSG00000152377
Uniprot IDs		P08253	Q08629
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis	Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Metabolic Process Endopeptidase Activity Luteinization Cellular Response To Amino Acid Stimulus Metalloendopeptidase Activity Cellular Response To UV-A Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Skeletal System Morphogenesis Response To Amino Acid Response To UV-A Metallopeptidase Activity Serine-type Endopeptidase Activity Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Embryonic Cranial Skeleton Morphogenesis Face Morphogenesis Endodermal Cell Differentiation Ovulation Cycle Process Cellular Response To Stress Cellular Response To Chemical Stress Ovarian Follicle Development Angiogenesis Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Response To Estrogen Catabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Macromolecule Catabolic Process Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Platelet-derived Growth Factor Alpha-receptor Activity Regulation Of Locomotion Extracellular Matrix Embryonic Skeletal System Morphogenesis Tissue Remodeling Cellular Response To UV Peptidase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Proteolysis Lung Development Cellular Response To Light Stimulus Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Platelet-derived Growth Factor Receptor-ligand Complex
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