MMP2 and KISS1

Number of citations: 0 (PubMedID 12879005)
Data Source: HPRD (in vitro, in vivo)

		MMP2	KISS1
Name		matrix metallopeptidase 2	KiSS-1 metastasis suppressor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Kisspeptin Receptor Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin	None
Diseases		Choriocarcinoma Penile cancer Torg-Winchester syndrome	None
GWAS		Heel bone mineral density ( 30598549 ) Lack of premeditation ( 30718321 ) Refractive error ( 32231278 )	Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (hypomanic personality scale) ( 28525603 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 )
Interacting Genes		40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	9 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9 UBQLN2
Entrez ID		4313	3814
HPRD ID		00386	04475
Ensembl ID		ENSG00000087245	ENSG00000170498
Uniprot IDs		P08253	Q15726
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78	8XGS 8ZJD
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis	Collagen Catabolic Process Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Metalloendopeptidase Activity Metallopeptidase Activity Endodermal Cell Differentiation Extracellular Matrix Peptidase Activity Extracellular Matrix Disassembly Response To Amyloid-beta Protein Metabolic Process Proteolysis Cellular Response To UV-A Cellular Response To UV Endopeptidase Activity Response To Light Stimulus Golgi Lumen Response To UV-A Cellular Response To Light Stimulus Chondrocyte Proliferation Skeletal System Morphogenesis Extracellular Space Craniofacial Suture Morphogenesis Ossification Response To Radiation Serine-type Endopeptidase Activity Response To UV Metalloaminopeptidase Activity Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Skeletal System Development Embryonic Cranial Skeleton Morphogenesis Endochondral Ossification Positive Regulation Of Cell Migration Response To Mechanical Stimulus Zinc Ion Binding Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Macromolecule Metabolic Process Ovarian Follicle Development Ephrin Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling