MMP2 and KISS1

Number of citations of the paper that reports this interaction (PMID 12879005)
19

Data Source:
HPRD (in vivo, in vitro)

		MMP2	KISS1
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	KiSS-1 metastasis-suppressor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Extracellular Region
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Cytoskeleton Organization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	7 interactors: APP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9
Entrez ID		4313	3814
HPRD ID		00386	04475
Ensembl ID		ENSG00000087245	ENSG00000170498
Uniprot IDs		P08253	Q15726
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Ossification Endoderm Development Chondrocyte Proliferation Formation Of Primary Germ Layer Craniofacial Suture Morphogenesis Skeletal System Development Gastrulation Embryonic Morphogenesis Proteolysis Positive Regulation Of Catalytic Activity Neurogenesis Response To External Stimulus Skeletal System Morphogenesis Endochondral Ossification Response To Abiotic Stimulus Axon Guidance Nervous System Development Embryonic Cranial Skeleton Morphogenesis Embryo Development System Development Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Embryo Implantation Locomotion Endochondral Bone Morphogenesis Reproductive Process Ephrin Receptor Signaling Pathway Axonogenesis Multicellular Organismal Development Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Organ Development Bone Morphogenesis Synaptic Growth At Neuromuscular Junction Embryonic Skeletal System Morphogenesis Neuron Projection Morphogenesis Regulation Of Protein Binding Positive Regulation Of Peptidase Activity
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	ahead alleles beyond compelling critically decade discusses embryo fertility follicular hypothalamic implantation implicating kisspeptin lie mammals manipulated neuroendocrine oocyte ovulation placentation playing powerful reproductive researchers steroid strides tremendous
Tagcloud (Intersection) ?