COL7A1 and MIA3

Number of citations of the paper that reports this interaction (PubMedID 19269366)
0

Data Source:
BioGRID (pull down)

		COL7A1	MIA3
Description		collagen type VII alpha 1 chain	MIA SH3 domain ER export factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Peptidase Inhibitor Activity	Protein Binding Cargo Receptor Activity
	Biological Process	Cell Adhesion Epidermis Development Endodermal Cell Differentiation	Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Leukocyte Migration Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Negative Regulation Of Cell Adhesion Protein Secretion Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Migration Vesicle Cargo Loading Wound Healing Lipoprotein Transport System Development Protein Localization To Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Migration
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs
Diseases		Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial Transient bullous dermolysis of the newborn
GWAS		Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Coronary artery disease ( 26343387 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609)
Interacting Genes		15 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 SHKBP1 THBS1 ZC3H7A	17 interacting genes: CACNA1A CEP55 CLIC3 COL7A1 FXR2 HOMER3 HSD17B14 ITGAX LENG8 MTNR1B NCK2 PRDM14 SEC16A SEC23A SEC24C TRIM27 UBC
Entrez ID		1294	375056
HPRD ID		00358	18918
Ensembl ID		ENSG00000114270	ENSG00000154305
Uniprot IDs		Q02388 Q59F16	Q5JRA6
PDB IDs			5KYN 5KYU 5KYW 7R3M
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Extracellular Region Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Space Extracellular Structure Organization Extracellular Matrix Organization Laminin-5 Complex Regulation Of Cell Adhesion Endodermal Cell Differentiation Endoplasmic Reticulum Lumen Tube Morphogenesis Morphogenesis Of An Epithelium Intramembranous Ossification Retinal Blood Vessel Morphogenesis Bone Trabecula Formation Fibrinogen Complex Tissue Morphogenesis Blood Coagulation, Fibrin Clot Formation Retina Vasculature Morphogenesis In Camera-type Eye Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Branching Involved In Salivary Gland Morphogenesis Cellular Response To Amino Acid Stimulus Proteoglycan Binding Collagen-activated Signaling Pathway Cell Adhesion Negative Regulation Of NLRP3 Inflammasome Complex Assembly Blood Vessel Morphogenesis Protease Binding Response To Hyperoxia Animal Organ Development Skeletal System Morphogenesis Angiogenesis Protein Activation Cascade Negative Regulation Of Cell Adhesion Response To Amino Acid Anatomical Structure Morphogenesis Ossification Branching Morphogenesis Of An Epithelial Tube Receptor Ligand Activity Developmental Process Ameboidal-type Cell Migration Integrin Binding	Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading
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