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COL7A1 and THBS1
Number of citations of the paper that reports this interaction (PMID
9840442
)
5
Data Source:
HPRD
(two hybrid)
COL7A1
THBS1
Gene Name
collagen, type VII, alpha 1
thrombospondin 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Collagen Type VII Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Identical Protein Binding
Phosphatidylserine Binding
Glycoprotein Binding
Fibronectin Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Identical Protein Binding
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Fibrinogen Binding
Collagen V Binding
Biological Process
Cell Adhesion
Epidermis Development
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Endodermal Cell Differentiation
Activation Of MAPK Activity
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Platelet Degranulation
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Outflow Tract Morphogenesis
Endocardial Cushion Development
Growth Plate Cartilage Development
Protein O-linked Glycosylation
Immune Response
Response To Unfolded Protein
Cell Cycle Arrest
Cell Adhesion
Blood Coagulation
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Cell-substrate Adhesion
Cell Migration
Negative Regulation Of Angiogenesis
Peptide Cross-linking
Platelet Activation
Positive Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of CGMP Metabolic Process
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Protein O-linked Fucosylation
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Response To Drug
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Collagen formation
Laminin interactions
Collagen degradation
Anchoring fibril formation
Integrin cell surface interactions
Collagen biosynthesis and modifying enzymes
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures
Signaling by PDGF
Post-translational protein modification
Non-integrin membrane-ECM interactions
Platelet degranulation
O-glycosylation of TSR domain-containing proteins
O-linked glycosylation
Syndecan interactions
Response to elevated platelet cytosolic Ca2+
Integrin cell surface interactions
Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions
14 interactors:
BMP1
COL1A1
COL4A1
FBXL2
FN1
HSPA8
LAMA1
LAMA5
LAMB3
LAMC2
MMP2
SHKBP1
THBS1
ZC3H7A
39 interactors:
CALCR
CALR
CD36
CD47
CFH
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL7A1
CORO1A
CTSG
DCN
DHFR
ELANE
F2
FGA
FGF2
FN1
HRG
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
PDGFB
PLG
SCARB2
SPARC
TFPI
TGFB1
TNFAIP6
TNFRSF11B
Entrez ID
1294
7057
HPRD ID
00358
01765
Ensembl ID
ENSG00000114270
Uniprot IDs
Q02388
Q59F16
P07996
PDB IDs
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Extracellular Structure Organization
Tissue Development
Blood Vessel Development
Vasculature Development
Cell-substrate Junction Assembly
Anatomical Structure Morphogenesis
Blood Vessel Morphogenesis
Locomotion
Cardiovascular System Development
Movement Of Cell Or Subcellular Component
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Endodermal Cell Differentiation
Cell Morphogenesis Involved In Differentiation
Anatomical Structure Development
Retinal Blood Vessel Morphogenesis
Cell Junction Assembly
Endoderm Formation
Cellular Response To Amino Acid Stimulus
Developmental Process
Collagen Catabolic Process
Organ Morphogenesis
Intramembranous Ossification
Collagen Metabolic Process
Cell Morphogenesis
Cell Differentiation
Multicellular Organismal Macromolecule Metabolic Process
Skeletal System Morphogenesis
Bone Trabecula Formation
Endoderm Development
Multicellular Organismal Metabolic Process
Multicellular Organismal Development
Cell Adhesion
Retina Vasculature Morphogenesis In Camera-type Eye
Hemidesmosome Assembly
Response To Amino Acid
Bone Trabecula Morphogenesis
Axon Guidance
Formation Of Primary Germ Layer
System Development
Cell Projection Morphogenesis
Cell Part Morphogenesis
Retina Vasculature Development In Camera-type Eye
Morphogenesis Of A Polarized Epithelium
Cellular Response To Acid Chemical
Branching Involved In Salivary Gland Morphogenesis
Gastrulation
Platelet Activation
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Disassembly
Wound Healing
Platelet Activation
Response To Wounding
Platelet Degranulation
Blood Coagulation
Hemostasis
Vesicle-mediated Transport
Collagen Catabolic Process
Regulation Of Locomotion
Response To External Stimulus
Collagen Metabolic Process
Regulation Of Body Fluid Levels
Cardiovascular System Development
Regulation Of Cell Migration
Multicellular Organismal Macromolecule Metabolic Process
Locomotion
Multicellular Organismal Metabolic Process
Regulation Of Cell Motility
Blood Vessel Development
Vasculature Development
Response To Stimulus
Regulation Of Cellular Component Movement
Tissue Development
Response To Stress
Leukocyte Migration
Response To Organic Substance
Movement Of Cell Or Subcellular Component
Negative Regulation Of Wound Healing
Endocytosis
Cell Migration
Regulation Of Wound Healing
Cell Activation
Blood Vessel Morphogenesis
Cell Motility
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Anatomical Structure Morphogenesis
Exocytosis
Positive Regulation Of Cellular Component Movement
Immune System Process
Positive Regulation Of Locomotion
Regulation Of Blood Coagulation
Multicellular Organismal Development
Negative Regulation Of Blood Coagulation
Anatomical Structure Development
Negative Regulation Of Coagulation
System Development
Tagcloud
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
map2k7
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs2
Tagcloud (Difference)
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
map2k7
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
serpinb5
serpine1
thbs2
Tagcloud (Intersection)
?