MMP2 and COL6A3

Number of citations of the paper that reports this interaction (PMID 8862926)
5

Data Source:
HPRD (in vitro)

		MMP2	COL6A3
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	collagen, type VI, alpha 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Vesicle Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Cell Adhesion Axon Guidance Muscle Organ Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs		Marimastat Captopril SC-74020
Diseases
GWAS			Aging (time to event) ( 21782286)
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	1 interactors: MMP2
Entrez ID		4313	1293
HPRD ID		00386	00371
Ensembl ID		ENSG00000087245	ENSG00000163359
Uniprot IDs		P08253	B7ZW00 D9ZGF2 E9PCV6 P12111 Q63HQ4 Q8N4Z1
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU	1KNT 1KTH 1KUN 2KNT
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Intramembranous Ossification Bone Trabecula Formation Blood Vessel Maturation Bone Trabecula Morphogenesis Face Morphogenesis Endodermal Cell Differentiation Head Morphogenesis Trabecula Morphogenesis Face Development Endoderm Formation Body Morphogenesis Cellular Response To Amino Acid Stimulus Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Response To Amino Acid Formation Of Primary Germ Layer Cellular Response To Acid Chemical Positive Regulation Of Innate Immune Response Gastrulation Female Pregnancy Regulation Of Innate Immune Response Skeletal System Morphogenesis Ossification Response To Hypoxia Angiogenesis Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Blood Vessel Morphogenesis
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	alveolar astrocyte causing challenges comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 kif23 lox lymphocyte lymphocytic methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	alveolar astrocyte causing challenges comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 kif23 lox lymphocyte lymphocytic methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized
Tagcloud (Intersection) ?