COL7A1 and SHKBP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		COL7A1	SHKBP1
Description		collagen type VII alpha 1 chain	SH3KBP1 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Lysosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Peptidase Inhibitor Activity	Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Epidermis Development Endodermal Cell Differentiation	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization	CDC42 GTPase cycle
Drugs
Diseases		Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial Transient bullous dermolysis of the newborn
GWAS		Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Carotid intima media thickness (mean) ( 31801372) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Hemoglobin levels ( 32327693)
Interacting Genes		15 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 SHKBP1 THBS1 ZC3H7A	14 interacting genes: CCNG1 COL7A1 CUL3 GRB2 HSP90AA1 HSP90AB1 LXN NR3C1 PIN1 PRPF3 SH3KBP1 UBC WEE2-AS1 YWHAG
Entrez ID		1294	92799
HPRD ID		00358	15338
Ensembl ID		ENSG00000114270	ENSG00000160410
Uniprot IDs		Q02388 Q59F16	Q8TBC3
PDB IDs			4CRH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Extracellular Region Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Space Extracellular Structure Organization Extracellular Matrix Organization Laminin-5 Complex Regulation Of Cell Adhesion Endodermal Cell Differentiation Endoplasmic Reticulum Lumen Tube Morphogenesis Morphogenesis Of An Epithelium Intramembranous Ossification Retinal Blood Vessel Morphogenesis Bone Trabecula Formation Fibrinogen Complex Tissue Morphogenesis Blood Coagulation, Fibrin Clot Formation Retina Vasculature Morphogenesis In Camera-type Eye Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Branching Involved In Salivary Gland Morphogenesis Cellular Response To Amino Acid Stimulus Proteoglycan Binding Collagen-activated Signaling Pathway Cell Adhesion Negative Regulation Of NLRP3 Inflammasome Complex Assembly Blood Vessel Morphogenesis Protease Binding Response To Hyperoxia Animal Organ Development Skeletal System Morphogenesis Angiogenesis Protein Activation Cascade Negative Regulation Of Cell Adhesion Response To Amino Acid Anatomical Structure Morphogenesis Ossification Branching Morphogenesis Of An Epithelial Tube Receptor Ligand Activity Developmental Process Ameboidal-type Cell Migration Integrin Binding	Regulation Of Protein Modification Process Regulation Of Protein Stability Ubiquitin Protein Ligase Binding Tau Protein Binding Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Protein-RNA Complex Assembly Protein Stabilization RNA Binding Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Identical Protein Binding Response To Temperature Stimulus Telomere Maintenance Via Telomere Lengthening Protein-containing Complex Assembly Protein Folding Chaperone Complex COP9 Signalosome Regulation Of Biological Quality ATP-dependent Protein Folding Chaperone Endodermal Cell Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Ubiquitination Positive Regulation Of Nitric Oxide Metabolic Process Protein-containing Complex Organization Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Collagen Type VII Trimer Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity CTP Binding DATP Binding Cellular Response To Heat Cis-trans Isomerase Activity Cellular Response To Stress Regulation Of Post-translational Protein Modification Protein Folding Chaperone Nucleoplasm Response To Stress Response To Hormone Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation
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