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MMP2 and MMP25
Number of citations of the paper that reports this interaction (PubMedID
14583471
)
0
Data Source:
HPRD
(in vitro)
MMP2
MMP25
Description
matrix metallopeptidase 2
matrix metallopeptidase 25
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Plasma Membrane
Membrane
Sarcomere
Extracellular Matrix
Extracellular Region
Extracellular Space
Plasma Membrane
Membrane
Extracellular Matrix
Specific Granule Membrane
Side Of Membrane
Molecular Function
Fibronectin Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Metalloendopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Angiogenesis
Ovarian Follicle Development
Ovulation From Ovarian Follicle
Luteinization
Response To Hypoxia
Blood Vessel Maturation
Intramembranous Ossification
Proteolysis
Response To Oxidative Stress
Negative Regulation Of Cell Adhesion
Heart Development
Female Pregnancy
Embryo Implantation
Parturition
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Peripheral Nervous System Axon Regeneration
Response To Activity
Cell Migration
Extracellular Matrix Disassembly
Protein Catabolic Process
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Response To Retinoic Acid
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Endodermal Cell Differentiation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Response To Estrogen
Negative Regulation Of Vasoconstriction
Ephrin Receptor Signaling Pathway
Macrophage Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Skeletal System Morphogenesis
Tissue Remodeling
Response To Electrical Stimulus
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Prostate Gland Epithelium Morphogenesis
Trophoblast Cell Migration
Cellular Response To Amino Acid Stimulus
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-1
Cellular Response To Estradiol Stimulus
Cellular Response To UV-A
Cellular Response To Fluid Shear Stress
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Proteolysis
Inflammatory Response
Extracellular Matrix Organization
Collagen Catabolic Process
Hard Palate Development
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells
Interleukin-4 and Interleukin-13 signaling
Extra-nuclear estrogen signaling
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Drugs
Marimastat
Captopril
SC-74020
Halofuginone
AE-941
Endostatin
Oleandrin
Marimastat
Fenofibrate
Fenofibric acid
Diseases
Choriocarcinoma
Penile cancer
Torg-Winchester syndrome
GWAS
Heel bone mineral density (
30598549
)
Lack of premeditation (
30718321
)
Refractive error (
32231278
)
Interacting Genes
40 interacting genes:
A2M
ACAN
BACE1
BCAN
CAPN3
CCL7
CCN5
CLDN1
COL18A1
COL1A1
COL6A3
COL7A1
CXCL12
DCN
EPHB2
FGFR1
HAPLN1
HSP90AA1
IGFBP3
IL1B
ITGAV
KISS1
LCN2
LGALS3
MMP14
MMP17
MMP25
MTDH
MTNR1A
MTNR1B
PZP
REL
SPOCK1
TGFB1
THBS1
THBS2
TIMP1
TIMP2
TIMP3
TIMP4
3 interacting genes:
CLU
MEOX2
MMP2
Entrez ID
4313
64386
HPRD ID
00386
07090
Ensembl ID
ENSG00000087245
ENSG00000008516
Uniprot IDs
P08253
Q9NPA2
PDB IDs
1CK7
1CXW
1EAK
1GEN
1GXD
1HOV
1J7M
1KS0
1QIB
1RTG
3AYU
7XGJ
7XJO
8H78
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Space
Extracellular Region
Peptidase Inhibitor Activity
Protease Binding
Metalloendopeptidase Inhibitor Activity
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Locomotion
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Membrane Protein Ectodomain Proteolysis
Cell Adhesion
Positive Regulation Of Developmental Process
Response To Cytokine
Response To Peptide
Positive Regulation Of Mononuclear Cell Migration
Response To Hormone
Skeletal System Development
Regulation Of Apoptotic Process
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Cell Migration
Extracellular Matrix Binding
Regulation Of Mononuclear Cell Migration
Integrin Binding
Positive Regulation Of Leukocyte Migration
Perineuronal Net
Negative Regulation Of Multicellular Organismal Process
Serine-type Endopeptidase Inhibitor Activity
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Response To Carbohydrate
Regulation Of Proteolysis
Regulation Of Developmental Process
Basement Membrane
Regulation Of Cell Junction Assembly
Regulation Of Anatomical Structure Morphogenesis
Cell Motility
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Developmental Process
Golgi Lumen
Response To Xenobiotic Stimulus
Negative Regulation Of Metallopeptidase Activity
Angiogenesis
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Spherical High-density Lipoprotein Particle
Negative Regulation Of Activation Of Membrane Attack Complex
Regulation Of Apoptotic Signaling Pathway
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Perinuclear Endoplasmic Reticulum Lumen
Positive Regulation Of Neurofibrillary Tangle Assembly
Microglial Cell Proliferation
Protein Import
Positive Regulation Of Inclusion Body Assembly
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Complement-dependent Cytotoxicity
Central Nervous System Myelin Maintenance
Regulation Of Intrinsic Apoptotic Signaling Pathway
Neurofibrillary Tangle
Chromaffin Granule
Regulation Of Neuronal Signal Transduction
Regulation Of Neurofibrillary Tangle Assembly
Positive Regulation Of Amyloid Fibril Formation
Immune Complex Clearance
Angiogenesis
Somite Specification
Intramembranous Ossification
Ovulation From Ovarian Follicle
Luteinization
Blood Vessel Maturation
Parturition
Peripheral Nervous System Axon Regeneration
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Trophoblast Cell Migration
Cellular Response To UV-A
Bone Trabecula Formation
Protein Carrier Chaperone
Negative Regulation Of Amyloid Fibril Formation
Protein Targeting To Vacuole Involved In Autophagy
Regulation Of Complement-dependent Cytotoxicity
Negative Regulation Of Complement Activation
Response To Misfolded Protein
Response To UV-A
Ovulation
Negative Regulation Of Vasoconstriction
Positive Regulation Of Programmed Cell Death
Apical Dendrite
Myelin Maintenance
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Apoptotic Process
Regulation Of Amyloid Fibril Formation
Reverse Cholesterol Transport
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Tagcloud (Intersection)
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