MMP2 and MMP25

Number of citations of the paper that reports this interaction (PMID 8663332)
79

Data Source:
HPRD (in vitro)

		MMP2	MMP25
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	matrix metallopeptidase 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Proteinaceous Extracellular Matrix Plasma Membrane Membrane Integral Component Of Membrane Anchored Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Proteolysis Inflammatory Response Hard Palate Development
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	2 interactors: CLU MMP2
Entrez ID		4313	64386
HPRD ID		00386	07090
Ensembl ID		ENSG00000087245	ENSG00000008516
Uniprot IDs		P08253	Q9NPA2
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Maintenance Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Positive Regulation Of Beta-amyloid Formation Intramembranous Ossification Negative Regulation Of Protein Oligomerization Positive Regulation Of Immune Response Bone Trabecula Formation Negative Regulation Of Beta-amyloid Formation Blood Vessel Maturation Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Glial Cell Proliferation Response To Misfolded Protein Regulation Of Immune Response Regulation Of Beta-amyloid Formation Bone Trabecula Morphogenesis Positive Regulation Of Immune System Process Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelination Cell Morphogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Oligomerization Macrophage Activation Release Of Cytochrome C From Mitochondria Myelin Maintenance Face Morphogenesis Regulation Of Immune System Process Endodermal Cell Differentiation Head Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process Oligodendrocyte Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Trabecula Morphogenesis Face Development Endoderm Formation Positive Regulation Of Tumor Necrosis Factor Production Body Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Amino Acid Stimulus
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	19k adamts4 bmp5 col4a1 compugen foxp1 fractured fst gadd45b gsn ibsp inhba itgb2 lowess mepe morphogenic nherf1 oa op osteocytes pde4a print ptk9 subchondral tgfb1 twist1 vcam1 wingless wnt5b
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	19k adamts4 bmp5 col4a1 compugen foxp1 fractured fst gadd45b gsn ibsp inhba itgb2 lowess mepe morphogenic nherf1 oa op osteocytes pde4a print ptk9 subchondral tgfb1 twist1 vcam1 wingless wnt5b
Tagcloud (Intersection) ?