MMP2 and THBS2

Number of citations: 0 (PubMedID 10900205)
Data Source: HPRD (two hybrid, in vitro)

		MMP2	THBS2
Name		matrix metallopeptidase 2	thrombospondin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Matrix Platelet Alpha Granule
	Molecular Function	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs		Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin	None
Diseases		Choriocarcinoma Penile cancer Torg-Winchester syndrome	None
GWAS		Heel bone mineral density ( 30598549 ) Lack of premeditation ( 30718321 ) Refractive error ( 32231278 )	Anorectal malformation ( 31136621 ) Blood protein levels ( 30072576 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Central corneal thickness ( 29760442 32528159 ) Common carotid intima-media thickness in HIV negative individuals ( 29206233 ) Copper levels ( 26025379 ) Dimensional psychopathology (Cognitive) ( 29496196 ) Haemorrhoidal disease ( 33888516 ) Joint mobility (Beighton score) ( 27182965 ) Liver disease severity in Alagille syndrome ( 28090565 ) Obesity-related traits ( 23251661 ) Pulse pressure ( 27841878 28135244 )
Interacting Genes		40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	4 interacting genes: MMP2 MMP9 THBS3 UBC
Entrez ID		4313	7058
HPRD ID		00386	01766
Ensembl ID		ENSG00000087245	ENSG00000186340
Uniprot IDs		P08253	A0A7I2V585 P35442
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78	1YO8 2RHP
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis	Cellular Response To UV-A Bone Trabecula Formation Response To UV-A Collagen Catabolic Process Embryo Implantation Endodermal Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Extracellular Matrix Response To Amyloid-beta Collagen Metabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Endopeptidase Activity Cellular Response To UV Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Process Metalloendopeptidase Activity Positive Regulation Of Programmed Cell Death Cellular Response To Light Stimulus Ossification Metallopeptidase Activity Brain Renin-angiotensin System Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Developmental Maturation Intramembranous Ossification Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Extracellular Matrix Organization Blood Vessel Maturation Extracellular Structure Organization Peripheral Nervous System Axon Regeneration Trophoblast Cell Migration Ovulation From Ovarian Follicle Heart Development Luteinization Parturition Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Meiotic Nuclear Division Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ossification Involved In Bone Maturation Proteolysis Positive Regulation Of Keratinocyte Migration