MMP2 and THBS2

Number of citations of the paper that reports this interaction (PMID 10900205)
42

Data Source:
HPRD (in vitro, two hybrid)

		MMP2	THBS2
Gene Name		matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	thrombospondin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere	Extracellular Region Basement Membrane Platelet Alpha Granule
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding	Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix	Signaling by PDGF Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs		Marimastat Captopril SC-74020
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4	3 interactors: MMP2 MMP9 THBS3
Entrez ID		4313	7058
HPRD ID		00386	01766
Ensembl ID		ENSG00000087245	ENSG00000186340
Uniprot IDs		P08253	P35442
PDB IDs		1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU	1YO8 2RHP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process	Bone Trabecula Formation Bone Trabecula Morphogenesis Ossification Endodermal Cell Differentiation Trabecula Morphogenesis Skeletal System Development Endoderm Formation Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Formation Of Primary Germ Layer Gastrulation Female Pregnancy Skeletal System Morphogenesis Tissue Development Positive Regulation Of Receptor Binding Positive Regulation Of Keratinocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Intramembranous Ossification Anatomical Structure Morphogenesis Axonogenesis Blood Vessel Maturation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ossification Involved In Bone Maturation Chemotaxis Bone Maturation Organ Development Neuron Projection Morphogenesis Growth Plate Cartilage Development Embryonic Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cation Channel Activity Macrophage Differentiation Cell Morphogenesis Involved In Differentiation Endochondral Bone Growth Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Face Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis
Tagcloud ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1
Tagcloud (Difference) ?		5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1
Tagcloud (Intersection) ?