COL7A1 and LAMC2

Number of citations of the paper that reports this interaction (PubMedID 9989793)
0

Data Source:
HPRD (in vivo, in vitro)

		COL7A1	LAMC2
Description		collagen type VII alpha 1 chain	laminin subunit gamma 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Basement Membrane Laminin-2 Complex Extracellular Space Cell Cortex Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Peptidase Inhibitor Activity	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Cell Adhesion Epidermis Development Endodermal Cell Differentiation	Cell Adhesion Positive Regulation Of Cell Population Proliferation Epidermis Development Positive Regulation Of Cell Migration
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial Transient bullous dermolysis of the newborn	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Acne (severe) ( 30542056) Blood protein levels ( 30072576) Clozapine-induced agranulocytosis ( 25187353) HDL cholesterol ( 21347282) Low density lipoprotein cholesterol levels ( 32154731) Morning person ( 30696823) Systemic lupus erythematosus ( 21408207)
Interacting Genes		15 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 SHKBP1 THBS1 ZC3H7A	7 interacting genes: BMP1 COL7A1 CSF1R FBLN2 LAMB3 NID1 SLA2
Entrez ID		1294	3918
HPRD ID		00358	01031
Ensembl ID		ENSG00000114270	ENSG00000058085
Uniprot IDs		Q02388 Q59F16	Q13753
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Extracellular Region Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Extracellular Space Extracellular Structure Organization Extracellular Matrix Organization Laminin-5 Complex Regulation Of Cell Adhesion Endodermal Cell Differentiation Endoplasmic Reticulum Lumen Tube Morphogenesis Morphogenesis Of An Epithelium Intramembranous Ossification Retinal Blood Vessel Morphogenesis Bone Trabecula Formation Fibrinogen Complex Tissue Morphogenesis Blood Coagulation, Fibrin Clot Formation Retina Vasculature Morphogenesis In Camera-type Eye Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Branching Involved In Salivary Gland Morphogenesis Cellular Response To Amino Acid Stimulus Proteoglycan Binding Collagen-activated Signaling Pathway Cell Adhesion Negative Regulation Of NLRP3 Inflammasome Complex Assembly Blood Vessel Morphogenesis Protease Binding Response To Hyperoxia Animal Organ Development Skeletal System Morphogenesis Angiogenesis Protein Activation Cascade Negative Regulation Of Cell Adhesion Response To Amino Acid Anatomical Structure Morphogenesis Ossification Branching Morphogenesis Of An Epithelial Tube Receptor Ligand Activity Developmental Process Ameboidal-type Cell Migration Integrin Binding	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Binding Endodermal Cell Differentiation Collagen Type VII Trimer SREBP-SCAP Complex CSF1-CSF1R Complex Macrophage Colony-stimulating Factor Receptor Activity Response To Vitamin B3 Extracellular Region
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