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CLK2 and KLHL2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
CLK2
KLHL2
Gene Name
CDC-like kinase 2
kelch-like family member 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nuclear Speck
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Actin Binding
Protein Binding
Biological Process
Protein Phosphorylation
Response To Ionizing Radiation
Peptidyl-tyrosine Phosphorylation
Response To Retinoic Acid
Regulation Of RNA Splicing
Negative Regulation Of Gluconeogenesis
Protein Autophosphorylation
Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
30 interactors:
AKT1
CLK3
CPSF7
ECE1
GMCL1
KLHL2
LNX1
LUZP4
MRPL4
PRPF38A
PTPN1
RBM39
RNPS1
RSRP1
SDCBP
SNIP1
SNRNP70
SRPK2
SRRM1
TRIM27
U2AF1
UBE2I
UBL5
YTHDC1
YWHAG
ZNF263
ZNF394
ZNF398
ZNF473
ZRSR2
15 interactors:
ACTC1
BCAM
CCDC43
CLK2
CUL3
KLHL12
SDCBP
TMA16
TNPO2
TXNDC12
UBE2C
UBE2D1
WNK1
WNK4
ZNF114
Entrez ID
1196
11275
HPRD ID
04289
09311
Ensembl ID
ENSG00000176444
ENSG00000109466
Uniprot IDs
A8K7I0
B1AVT0
B7Z8N6
P49760
Q9BRG8
O95198
PDB IDs
3NR9
2XN4
Enriched GO Terms of Interacting Partners
?
MRNA Processing
RNA Processing
RNA Splicing
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Gene Expression
Termination Of RNA Polymerase II Transcription
RNA Metabolic Process
DNA-templated Transcription, Termination
MRNA 3'-end Processing
Cellular Nitrogen Compound Metabolic Process
RNA 3'-end Processing
Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of RNA Splicing
Spliceosomal Complex Assembly
Regulation Of MRNA Splicing, Via Spliceosome
MRNA Export From Nucleus
RNA Export From Nucleus
Negative Regulation Of Protein Kinase Activity
Negative Regulation Of Kinase Activity
Regulation Of RNA Metabolic Process
Regulation Of MRNA Processing
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleocytoplasmic Transport
Nuclear Transport
Cellular Process
Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Nuclear Export
MRNA Transport
Negative Regulation Of Transferase Activity
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Protein Phosphorylation
Protein Ubiquitination
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
RNA Transport
Protein Modification By Small Protein Conjugation
RNA Localization
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Phosphorylation
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Mitotic Metaphase/anaphase Transition
Regulation Of Chromosome Segregation
Negative Regulation Of Transferase Activity
Regulation Of Mitotic Nuclear Division
COPII Vesicle Coating
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
COPII-coated Vesicle Budding
Positive Regulation Of Cellular Protein Catabolic Process
Protein Polyubiquitination
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Vesicle Targeting, To, From Or Within Golgi
Regulation Of Proteasomal Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Regulation Of Chromosome Organization
Spindle Assembly Checkpoint
Protein K48-linked Ubiquitination
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Protein Catabolic Process
Protein Ubiquitination
Mitotic Spindle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Protein Monoubiquitination
Localization Within Membrane
Negative Regulation Of Chromosome Segregation
Vesicle Targeting
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Kinase Activity
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Cell Division
Proteasomal Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Positive Regulation Of Proteolysis
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Catalytic Activity
Cellular Protein Modification Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud
?
chek2
comprehensively
escc
esophageal
fance
fen1
gc
genetics
genotyped
germline
gtf2h3
han
hel308
linxian
mpg
mre11a
pole
polq
propensity
rad54b
rad54l
resampling
shanxi
smug1
snps
sum
tdg
validate
warranted
Tagcloud (Difference)
?
chek2
comprehensively
escc
esophageal
fance
fen1
gc
genetics
genotyped
germline
gtf2h3
han
hel308
linxian
mpg
mre11a
pole
polq
propensity
rad54b
rad54l
resampling
shanxi
smug1
snps
sum
tdg
validate
warranted
Tagcloud (Intersection)
?