CLK2 and CLK3

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		CLK2	CLK3
Gene Name		CDC-like kinase 2	CDC-like kinase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Response To Retinoic Acid Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: AKT1 CLK3 CPSF7 ECE1 GMCL1 KLHL2 LNX1 LUZP4 MRPL4 PRPF38A PTPN1 RBM39 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 TRIM27 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF263 ZNF394 ZNF398 ZNF473 ZRSR2	19 interactors: APP CLK2 HOXB6 HOXB7 KRTAP10-3 NEDD4 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RSRP1 SDCBP SLAMF7 SRPK2 SUV39H1 TINF2 YWHAG ZNF263
Entrez ID		1196	1198
HPRD ID		04289	04290
Ensembl ID		ENSG00000176444	ENSG00000179335
Uniprot IDs		A8K7I0 B1AVT0 B7Z8N6 P49760 Q9BRG8	B3KRI8 B3KTV2 P49761
PDB IDs		3NR9	2EU9 2EXE 2WU6 2WU7 3RAW
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression Termination Of RNA Polymerase II Transcription RNA Metabolic Process DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA 3'-end Processing Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Export From Nucleus RNA Export From Nucleus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Transcription, DNA-templated RNA Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Cellular Process Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Nuclear Export MRNA Transport Negative Regulation Of Transferase Activity Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Protein Phosphorylation Protein Ubiquitination Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Transport Protein Modification By Small Protein Conjugation RNA Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Phosphorylation	MRNA Processing Regulation Of RNA Splicing MRNA Metabolic Process RNA Metabolic Process RNA Processing RNA Splicing Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gene Expression Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Biosynthetic Process Immune System Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Neuromuscular Junction Development Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Nuclear Speck Organization Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Metabolic Process Cell Activation Regulation Of Cellular Process Cell Differentiation Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Protein ADP-ribosylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Synaptic Growth At Neuromuscular Junction Immune Response Negative Regulation Of Gene Expression Regulation Of Synapse Structure Or Activity Innate Immune Response Collateral Sprouting In Absence Of Injury Positive Regulation Of Organelle Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Protein Glycosylation Protein Targeting Regulation Of Organelle Organization Histone Methylation
Tagcloud ?		chek2 comprehensively escc esophageal fance fen1 gc genetics genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Difference) ?		chek2 comprehensively escc esophageal fance fen1 gc genetics genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Intersection) ?