CLK2 and CLASRP

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLK2	CLASRP
Description		CDC like kinase 2	CLK4 associating serine/arginine rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	MRNA Processing RNA Splicing
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21	14 interacting genes: APP ATXN1 CDK6 CLK1 CLK2 CLK3 CLK4 DAB1 DAZAP2 DYRK1A RHOXF2 SMAD3 SRPK2 VDR
Entrez ID		1196	11129
HPRD ID		04289	11552
Ensembl ID		ENSG00000176444	ENSG00000104859
Uniprot IDs		A8K7I0 B1AVT0 B7Z8N6 P49760	Q8N2M8
PDB IDs		3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity	Protein Serine/threonine/tyrosine Kinase Activity Protein Serine Kinase Activity Regulation Of RNA Splicing Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Speck Positive Regulation Of Gene Expression Identical Protein Binding Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Adult Locomotory Behavior ATP Binding Positive Regulation Of Biosynthetic Process Protein Phosphorylation Protein Serine/threonine Kinase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleotide Binding Transferase Activity Phosphorylation Negative Regulation Of MiRNA Transcription Adult Behavior Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Locomotory Behavior Negative Regulation Of RNA Metabolic Process Receptor Complex Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Bone Mineralization Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Dendrite Development Cyclin D2-CDK6 Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration
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