CLK2 and SRRM1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		CLK2	SRRM1
Description		CDC like kinase 2	serine and arginine repetitive matrix 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)
Interacting Genes		62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21	13 interacting genes: ABI1 CLK1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 SRRM4 YWHAG
Entrez ID		1196	10250
HPRD ID		04289	10441
Ensembl ID		ENSG00000176444	ENSG00000133226
Uniprot IDs		A8K7I0 B1AVT0 B7Z8N6 P49760	A0A0S2Z4W1 A0A0S2Z4Z6 A0A994J4Y3 A0A994J7H1 A0A994J7V4 B7Z7U0 Q8IYB3
PDB IDs		3NR9 5UNP 6FYI 6FYK 6FYL 6KHE	1MP1 6FF4 6FF7 7ABG 7ABH 7ABI 7DVQ 8I0P 8I0R
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity	Regulation Of RNA Splicing Nuclear Speck Regulation Of Primary Metabolic Process Nucleus Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of Metabolic Process Macromolecule Metabolic Process RNA Binding MRNA Metabolic Process Kinase Activity Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Double-strand Break Repair Protein Serine/threonine/tyrosine Kinase Activity Postsynaptic Cytosol Positive Regulation Of Viral Genome Replication MRNA Processing Regulation Of Gene Expression RNA Metabolic Process RNA Processing Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Protein Targeting Nucleoplasm Negative Regulation Of Translational Initiation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Regulation Of DNA Repair Protein Modification Process Protein Stabilization Cis-trans Isomerase Activity Positive Regulation Of Viral Process Identical Protein Binding Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Phosphorylation Protein Localization To Vacuole Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nucleic Acid Metabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity ATP Binding
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