RNF166 and UBE2U

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF166	UBE2U
Description		ring finger protein 166	ubiquitin conjugating enzyme E2 U
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	HULC Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination Innate Immune Response	Protein Polyubiquitination DNA Repair Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coffee consumption ( 31046077) Hair color ( 26926045)	Severe bacterial meningitis ( 31092817)
Interacting Genes		23 interacting genes: CYLD MAGEA1 MAGEC2 MKRN3 RNF41 SQSTM1 TRIM39 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UBE2Z USP2 XAF1	69 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF213 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		115992	148581
HPRD ID		15260	14599
Ensembl ID		ENSG00000158717	ENSG00000177414
Uniprot IDs		Q96A37	A0A0A0MRP4 A0A140VJY9 Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Catabolic Process Protein Monoubiquitination ATP Binding Protein Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus ISG15 Transferase Activity Negative Regulation Of Metabolic Process ISG15-protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Autoubiquitination Programmed Cell Death Cell Death Molecular Sequestering Activity Nucleoplasm Protein K6-linked Ubiquitination Cytosol Apoptotic Process Response To Interferon-beta Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Type I Interferon Production Negative Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activity Metal Ion Binding Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Suppression Of Viral Release By Host Protein Autoubiquitination Catabolic Process Transcription Coactivator Activity Protein K63-linked Ubiquitination Innate Immune Response Protein Catabolic Process Proteasomal Protein Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Response To Other Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Transferase Activity Response To Stress Response To External Biotic Stimulus Immune System Process Protein Sumoylation Immune Response Defense Response Defense Response To Virus Protein K48-linked Ubiquitination PRC1 Complex Regulation Of Type I Interferon Production Cytoplasm Regulation Of Viral Process Positive Regulation Of Catabolic Process Response To Virus PcG Protein Complex Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Viral Process SnoRNA Splicing
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