RNF166 and TRIM9

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF166	TRIM9
Description		ring finger protein 166	tripartite motif containing 9
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Cytoplasmic Vesicle Cell Projection Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination Innate Immune Response	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coffee consumption ( 31046077) Hair color ( 26926045)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		23 interacting genes: CYLD MAGEA1 MAGEC2 MKRN3 RNF41 SQSTM1 TRIM39 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UBE2Z USP2 XAF1	33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NRIP1 NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP
Entrez ID		115992	114088
HPRD ID		15260	05947
Ensembl ID		ENSG00000158717	ENSG00000100505
Uniprot IDs		Q96A37	A0A804HIL7 Q9C026
PDB IDs			2DB8 7B2S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Catabolic Process Protein Monoubiquitination ATP Binding Protein Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus ISG15 Transferase Activity Negative Regulation Of Metabolic Process ISG15-protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Autoubiquitination Programmed Cell Death Cell Death Molecular Sequestering Activity Nucleoplasm Protein K6-linked Ubiquitination Cytosol Apoptotic Process Response To Interferon-beta Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Type I Interferon Production Negative Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication	Protein Polyubiquitination Protein Destabilization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Anterograde Synaptic Vesicle Transport Protein Modification Process Regulation Of Protein Stability SUMO Transferase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Synaptic Vesicle Transport Establishment Of Vesicle Localization SH3 Domain Binding Vesicle Localization Vesicle Transport Along Microtubule Anterograde Axonal Transport Ubiquitin-protein Transferase Activity Protein Sumoylation Profilin Binding Vesicle Cytoskeletal Trafficking Protein Metabolic Process Zinc Ion Binding Axon Cytoplasm Axonal Transport Circadian Regulation Of Gene Expression Positive Regulation Of Autophagy BLOC-1 Complex Negative Regulation Of Cell Projection Organization Protein K63-linked Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Axo-dendritic Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Transport Along Microtubule Positive Regulation Of Proteolysis Regulation Of Viral Transcription Regulation Of Biological Quality Microtubule-based Transport Platelet Dense Granule Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Neuron Projection Development Rhythmic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Formaldehyde
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