RNF166 and MAGEA1

Number of citations: 60 (PubMedID 25590999)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		RNF166	MAGEA1
Name		ring finger protein 166	MAGE family member A1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Histone Deacetylase Binding
	Biological Process	Protein Polyubiquitination Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Protein Ubiquitination Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway
GWAS		Coffee consumption ( 31046077 ) Hair color ( 26926045 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: CYLD MAGEA1 MAGEC2 MKRN3 RNF41 SQSTM1 TRIM39 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UBE2Z USP2 XAF1	25 interacting genes: ABI2 CEP57L1 DNM1L HDAC1 HLA-A HLA-B HYPK LRSAM1 MDM4 MIEF1 NOTCH1 PBX3 PCGF6 RAB17 RNF166 S100A9 SELPLG SFN SGK1 SH3GLB2 SHFL SNW1 TRIM31 UQCRB ZNF564
Entrez ID		115992	4100
HPRD ID		15260	02059
Ensembl ID		ENSG00000158717	ENSG00000198681
Uniprot IDs		Q96A37	P43355
PDB IDs		Not available	1W72 3BO8
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Catabolic Process Protein Monoubiquitination ATP Binding Protein Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleus ISG15 Transferase Activity Negative Regulation Of Metabolic Process ISG15-protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Autoubiquitination Programmed Cell Death Cell Death Molecular Sequestering Activity Nucleoplasm Protein K6-linked Ubiquitination Cytosol Apoptotic Process Response To Interferon-beta Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Type I Interferon Production Negative Regulation Of Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication	TAP Binding Compartment Pattern Specification Protection From Natural Killer Cell Mediated Cytotoxicity MHC Class I Protein Complex Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Mitochondrial Fission Regulation Of Cellular Component Organization Response To External Biotic Stimulus Epidermal Cell Differentiation Negative Regulation Of Innate Immune Response Negative Regulation Of Myotube Differentiation Innate Immune Response Recycling Endosome Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Mitochondrial Fission Defense Response Host-mediated Perturbation Of Symbiont Process Notch Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Symbiont Modulation Of Process Of Another Organism Defense Response To Other Organism Response To Other Organism Positive Regulation Of Epidermal Cell Differentiation Host-mediated Perturbation Of Viral Transcription Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Mitochondrial Fission Lumenal Side Of Endoplasmic Reticulum Membrane Autophagy Detection Of Biotic Stimulus Positive Regulation Of Epidermis Development Endoderm Development Regulation Of Viral Process Positive Regulation Of Glial Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Posterior Compartment Specification Anterior Compartment Pattern Formation S100A9 Complex Viral Process