CKB and MLH1

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		CKB	MLH1
Gene Name		creatine kinase, brain	mutL homolog 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Extracellular Vesicular Exosome	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Substantia Nigra Development Cellular Chloride Ion Homeostasis Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Metabolism of amino acids and derivatives Creatine metabolism	Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs		Creatine
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACD ASB9 CKM ILK MLH1 POT1 PPP1CA SERP2 TAB1 TERF1 TINF2 TRIM63	74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1
Entrez ID		1152	4292
HPRD ID		00423	00390
Ensembl ID		ENSG00000166165	ENSG00000076242
Uniprot IDs		P12277	P40692 Q59EG3
PDB IDs		3B6R 3DRB 3DRE	3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Telomere Assembly Negative Regulation Of DNA Replication Telomere Maintenance Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Regulation Of DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Regulation Of Organelle Organization RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Chromosome Organization Protein Localization To Chromosome DNA Metabolic Process Positive Regulation Of Transferase Activity Cellular Component Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of DNA Replication Negative Regulation Of Protein ADP-ribosylation Meiotic Metaphase I Plate Congression Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Meiotic Spindle Midzone Assembly Phosphocreatine Biosynthetic Process Cell Aging Cellular Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Protein ADP-ribosylation Negative Regulation Of Mitotic Recombination Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Formation Via Telomerase Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Cellular Component Organization	Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction
Tagcloud ?			9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?			9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?