CKB and SMG5

		CKB	SMG5
Description		creatine kinase B	SMG5 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		Creatine metabolism RND3 GTPase cycle	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Creatine Phosphocreatine
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)	Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 29403010)
Interacting Genes		19 interacting genes: ACD ARIH2 ASB9 CKM CUL5 ERBB2 GOLGA2 ILK MLH1 OGT POT1 PPP1CA SERP2 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A	8 interacting genes: APP BTG3 SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		1152	23381
HPRD ID		00423	16869
Ensembl ID		ENSG00000166165	ENSG00000198952
Uniprot IDs		A0A0S2Z471 P12277 V9HWH2	Q9UPR3
PDB IDs		3B6R 3DRB 3DRE 6V9H 7BF1 7TUN	2HWY
Enriched GO Terms of Interacting Partners?		Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process	Telomeric DNA Binding Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus RNA Export From Nucleus Nuclear Transport Nucleocytoplasmic Transport Telomerase RNA Binding Telomerase Holoenzyme Complex Nuclear-transcribed MRNA Catabolic Process Nuclear Export MRNA Transport MRNA Catabolic Process RNA Transport RNA Catabolic Process Nucleobase-containing Compound Transport Intracellular Transport Protein-folding Chaperone Binding Regulation Of Telomere Maintenance Nucleobase-containing Compound Catabolic Process Exon-exon Junction Complex Cellular Localization Establishment Of Localization In Cell Regulation Of Dephosphorylation Chromosome, Telomeric Region Cytoplasm Macromolecule Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress MRNA Metabolic Process Regulation Of Chromosome Organization Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DNA Metabolic Process TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Chaperone-mediated Protein Complex Assembly RNA Metabolic Process G Protein-coupled Receptor Binding Regulation Of MiRNA Transcription Nucleus Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Response To Interleukin-1
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