CKB and DIO3

		CKB	DIO3
Description		creatine kinase B	iodothyronine deiodinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome	Endosome Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding	Thyroxine 5'-deiodinase Activity Oxidoreductase Activity Thyroxine 5-deiodinase Activity
	Biological Process	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle	Response To Hypoxia Apoptotic Process Positive Regulation Of Multicellular Organism Growth Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Retinal Cone Cell Development Brown Fat Cell Proliferation Retinal Cone Cell Apoptotic Process
Pathways		Creatine metabolism RND3 GTPase cycle	Regulation of thyroid hormone activity
Drugs		Creatine Phosphocreatine	Iopodic acid
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)	Metabolite levels ( 23823483) Pulse pressure ( 30224653) Type 1 diabetes ( 19966805)
Interacting Genes		19 interacting genes: ACD ARIH2 ASB9 CKM CUL5 ERBB2 GOLGA2 ILK MLH1 OGT POT1 PPP1CA SERP2 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A	3 interacting genes: APP PRMT5 PRMT7
Entrez ID		1152	1735
HPRD ID		00423	11867
Ensembl ID		ENSG00000166165	ENSG00000197406
Uniprot IDs		A0A0S2Z471 P12277 V9HWH2	P55073 Q86TU3
PDB IDs		3B6R 3DRB 3DRE 6V9H 7BF1 7TUN
Enriched GO Terms of Interacting Partners?		Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process	Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine N-methyltransferase Activity Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Protein Methylation Ribonucleoprotein Complex Binding Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Spliceosomal SnRNP Assembly Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Adrenergic Receptor Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Type II Interferon Production Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Kininogen Binding Deoxyribonuclease Inhibitor Activity Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Futile Creatine Cycle Peptidyl-arginine N-methylation Histone Arginine N-methyltransferase Activity Macromolecule Methylation Methyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus
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