CKB and IFI27

		CKB	IFI27
Description		creatine kinase B	interferon alpha inducible protein 27
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleus Nuclear Envelope Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding	Protein Binding Lamin Binding Identical Protein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Host-mediated Perturbation Of Viral Genome Replication Innate Immune Response Regulation Of Protein Export From Nucleus Defense Response To Virus Type I Interferon-mediated Signaling Pathway Pyroptotic Inflammatory Response Protein K48-linked Ubiquitination Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway
Pathways		Creatine metabolism RND3 GTPase cycle	Interferon alpha/beta signaling Modulation of host responses by IFN-stimulated genes
Drugs		Creatine Phosphocreatine
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)
Interacting Genes		19 interacting genes: ACD ARIH2 ASB9 CKM CUL5 ERBB2 GOLGA2 ILK MLH1 OGT POT1 PPP1CA SERP2 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A	4 interacting genes: APOC2 APOC4 CCND1 CDK4
Entrez ID		1152	3429
HPRD ID		00423	02479
Ensembl ID		ENSG00000166165	ENSG00000165949
Uniprot IDs		A0A0S2Z471 P12277 V9HWH2	P40305
PDB IDs		3B6R 3DRB 3DRE 6V9H 7BF1 7TUN
Enriched GO Terms of Interacting Partners?		Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process	Cyclin D1-CDK4 Complex High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Acylglycerol Homeostasis Triglyceride Homeostasis Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Cyclin D1-CDK6 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Bicellular Tight Junction Cyclin D3-CDK4 Complex Futile Creatine Cycle Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Lipid Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remodeling Re-entry Into Mitotic Cell Cycle Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Ketone Cellular Response To Ionomycin Phosphocreatine Biosynthetic Process Creatine Kinase Activity Spherical High-density Lipoprotein Particle Positive Regulation Of Triglyceride Catabolic Process Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Clearance Positive Regulation Of Cell Cycle Process Response To Vitamin E Nuclear Membrane Response To Alcohol Triglyceride-rich Lipoprotein Particle Remodeling
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