MTFR2 and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MTFR2	ALAS1
Description		mitochondrial fission regulator 2	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Mitochondrial Fission Mitochondrion Organization Aerobic Respiration	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		6 interacting genes: ALAS1 CFTR GOLGA2 MAGEA12 TFIP11 TRIM23	54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		113115	211
HPRD ID		16884	00505
Ensembl ID		ENSG00000146410	ENSG00000023330
Uniprot IDs		Q6P444	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Purine-containing Compound 5-aminolevulinate Synthase Activity Response To Nickel Cation Response To CAMP Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Heme O Biosynthetic Process Response To Herbicide Response To Cobalt Ion Response To Bile Acid Response To Platinum Ion Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Hemoglobin Biosynthetic Process Response To Alcohol Heme B Biosynthetic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Golgi Ribbon Formation Importin-alpha Family Protein Binding Golgi Disassembly Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Protection From Non-homologous End Joining At Telomere Hemoglobin Metabolic Process Protoporphyrinogen IX Metabolic Process Golgi Cis Cisterna Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Asymmetric Cell Division Golgi-associated Vesicle Membrane Telomere Maintenance In Response To DNA Damage Cellular Response To Forskolin Meiotic Spindle Assembly Response To Forskolin	Actin Monomer Binding
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