PNKP and TRIM37

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PNKP	TRIM37
Gene Name		polynucleotide kinase 3-phosphatase	tripartite motif containing 37
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		11284	4591
HPRD ID		09284	05463
Ensembl ID		ENSG00000039650	ENSG00000108395
Uniprot IDs		Q96T60	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs		2BRF 2W3O	3LRQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
Tagcloud ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?