PNKP and XRCC1

Number of citations of the paper that reports this interaction (PMID 11163244)
104

Data Source:
HPRD (in vitro, two hybrid)

		PNKP	XRCC1
Gene Name		polynucleotide kinase 3-phosphatase	X-ray repair complementing defective repair in Chinese hamster cells 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Nucleus Nucleoplasm
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Damaged DNA Binding Protein Binding Enzyme Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation	Single Strand Break Repair DNA Repair Base-excision Repair
Pathways			Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	16 interactors: APEX1 APLF APTX BRCA1 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 SUMO1
Entrez ID		11284	7515
HPRD ID		09284	01909
Ensembl ID		ENSG00000039650	ENSG00000073050
Uniprot IDs		Q96T60	B2RCY5 P18887 Q59HH7
PDB IDs		2BRF 2W3O	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation	DNA Repair Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair DNA Catabolic Process Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stress DNA-dependent DNA Replication DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis Response To Stimulus Response To Oxidative Stress DNA Catabolic Process, Endonucleolytic Aromatic Compound Catabolic Process Polynucleotide 3' Dephosphorylation Cellular Macromolecule Catabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Response To Inorganic Substance DNA Damage Response, Detection Of DNA Damage DNA Recombination Telomere Maintenance Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization DNA Ligation Regulation Of Nitrogen Compound Metabolic Process DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Catabolic Process Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Single Strand Break Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Protein ADP-ribosylation Cell Cycle Metabolic Process
Tagcloud ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Intersection) ?