PNKP and SUV39H1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PNKP	SUV39H1
Gene Name		polynucleotide kinase 3-phosphatase	suppressor of variegation 3-9 homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Organization Transcription, DNA-templated RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Gene Expression Viral Process Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	123 interactors: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C17orf82 C4orf17 C8orf74 CBX1 CBX4 CBX5 CCDC151 CCDC37 CDC23 CDCA4 CDCA7L CEP70 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GPATCH2L GTF2H2C_2 GTPBP2 H3F3C HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HIST1H3A HIST2H3A HIST3H3 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 LDHAL6B LENG8 LHX8 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 OPA3 PHF19 PML PNKP PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEX35 THRA TMEM11 TNFAIP1 U2AF1 WDFY3 WIZ ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF436 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZSCAN9
Entrez ID		11284	6839
HPRD ID		09284	02221
Ensembl ID		ENSG00000039650	ENSG00000101945
Uniprot IDs		Q96T60	B4DST0 O43463
PDB IDs		2BRF 2W3O	3MTS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation	RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Organelle Organization Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone Modification Histone H4 Deacetylation Cellular Process Regulation Of Cell Cycle Metabolic Process
Tagcloud ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Intersection) ?