PNKP and GZMK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PNKP	GZMK
Description		polynucleotide kinase 3'-phosphatase	granzyme K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break	Extracellular Region Extracellular Space Symbiont Cell Surface
	Molecular Function	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity	Serine-type Endopeptidase Activity Protein Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Pattern Recognition Receptor Activity
	Biological Process	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Activation Of Membrane Attack Complex Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Inflammatory Response Protein Maturation Positive Regulation Of Release Of Cytochrome C From Mitochondria Granzyme-mediated Programmed Cell Death Signaling Pathway Complement Activation, GZMK Pathway
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Blood protein levels ( 30072576)
Interacting Genes		50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP
Entrez ID		11284	3003
HPRD ID		09284	02872
Ensembl ID		ENSG00000039650	ENSG00000113088
Uniprot IDs		Q96T60	P49863
PDB IDs		2BRF 2W3O	1MZA 1MZD
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining	VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of RIG-I Signaling Pathway Damaged DNA Binding Double-strand Break Repair Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process DNA Repair Cellular Response To Misfolded Protein Regulation Of Programmed Cell Death Response To Misfolded Protein ERAD Pathway Base-excision Repair, Gap-filling Nucleus Ubiquitin Protein Ligase Binding V(D)J Recombination Regulation Of RIG-I Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Macromolecule Metabolic Process Organelle Organization DNA Damage Response Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Apoptotic Process Condensed Chromosome Regulation Of Metabolic Process Base-excision Repair Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Somatic Cell DNA Recombination Negative Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Basal Body Patch Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To Stress Telomere Maintenance Via Base-excision Repair
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