PNKP and RPRM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PNKP	RPRM
Description		polynucleotide kinase 3'-phosphatase	reprimo, TP53 dependent G2 arrest mediator homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break	Cytoplasm Membrane
	Molecular Function	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity	Protein Binding
	Biological Process	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Anti-saccade response ( 29064472) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549) Lung cancer ( 28604730) Recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	80 interacting genes: ADGRG3 AMIGO1 AQP6 ARFIP1 ASGR2 BNIP3 BSCL2 BTNL9 C16orf54 CD33 CD53 CD69 CLDN5 CLDN7 CLDN9 CLEC17A CLEC2D COQ8A CREB3 CXorf66 EHHADH EMP1 FAM209A FAM210B FATE1 FBXL19 FCGR1A FFAR2 FGD2 FKBP7 FNDC9 GAD2 GJA5 GJB3 GJB5 GNG13 GPR37L1 GPR42 GPX8 HHLA2 HIP1 HSD17B13 KCNJ6 LAPTM5 LHFPL5 LMNA LPAR6 MPP1 MS4A4A MTIF3 OPRD1 OPRM1 PBX3 PDZK1IP1 PLEKHF2 PNKP SCAND1 SDCBP SENP2 SLC18A1 SLC38A1 SMIM3 SNX11 SNX12 SNX3 SPACA1 SPCS1 STOM SUSD3 SYT16 TM4SF18 TMEM106C TMEM237 TMEM79 TMEM80 TMEM86B TSPO2 TTPA WDFY2 ZDHHC22
Entrez ID		11284	56475
HPRD ID		09284	18002
Ensembl ID		ENSG00000039650	ENSG00000177519
Uniprot IDs		Q96T60	Q9NS64
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining	Membrane Protein Binding Plasma Membrane Negative Regulation Of Early Endosome To Late Endosome Transport Connexin Complex Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Gap Junction Channel Activity Endoplasmic Reticulum Phosphatidylinositol Binding External Side Of Plasma Membrane Gap Junction Gamma-aminobutyric Acid Biosynthetic Process Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport
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