PNKP and ZNF639

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PNKP	ZNF639
Gene Name		polynucleotide kinase 3-phosphatase	zinc finger protein 639
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Nucleus Nucleoplasm
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Self-association Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation	Transcription, DNA-templated Positive Regulation Of Cell Growth Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Entry Into Host Cell
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	3 interactors: APTX CREBBP PNKP
Entrez ID		11284	51193
HPRD ID		09284	15882
Ensembl ID		ENSG00000039650	ENSG00000121864
Uniprot IDs		Q96T60	Q9UID6
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation	Polynucleotide 3' Dephosphorylation DNA Catabolic Process Cellular Response To Stress N-terminal Peptidyl-lysine Acetylation Nucleic Acid Phosphodiester Bond Hydrolysis Germ-line Stem Cell Maintenance Response To Oxidative Stress DNA Damage Response, Detection Of DNA Damage Aromatic Compound Catabolic Process Dephosphorylation N-terminal Protein Amino Acid Acetylation DNA Ligation DNA Repair Nucleotide-excision Repair, DNA Damage Removal Single Strand Break Repair Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress N-terminal Protein Amino Acid Modification DNA Catabolic Process, Exonucleolytic Cellular Response To DNA Damage Stimulus Regulation Of Cellular Response To Heat Cellular Macromolecule Catabolic Process DNA Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Nucleotide Phosphorylation Nucleobase-containing Compound Metabolic Process Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Embryonic Digit Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Nucleotide-excision Repair Regulation Of Smoothened Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Nitrogen Compound Metabolic Process
Tagcloud ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?