PNKP and ZNF639

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		PNKP	ZNF639
Description		polynucleotide kinase 3'-phosphatase	zinc finger protein 639
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Membrane Site Of Double-strand Break	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Endonuclease Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To Oxidative Stress Response To Radiation Positive Regulation Of Telomere Maintenance Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Gout (normal type) ( 32238385) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CISD2 CNTROB COL17A1 DRC4 DVL3 EIF4ENIF1 FADS6 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	12 interacting genes: APTX CREBBP CRYAA MCRS1 MPP1 PNKP PRPF18 RIN3 ZBTB24 ZNF250 ZNF792 ZNF837
Entrez ID		11284	51193
HPRD ID		09284	15882
Ensembl ID		ENSG00000039650	ENSG00000121864
Uniprot IDs		Q96T60	Q9UID6
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Protein Binding Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Synaptic Vesicle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Enzyme Binding Base-excision Repair Immunoglobulin V(D)J Recombination Regulation Of Synaptic Plasticity Regulation Of Transcription By Glucose Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Synaptic Vesicle Priming Negative Regulation Of Biosynthetic Process Protein Monoubiquitination Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Double-strand Break Repair Via Nonhomologous End Joining	Polynucleotide 3'-phosphatase Activity Damaged DNA Binding Positive Regulation Of DNA Repair Histone Acetyltransferase Complex DNA Repair Regulation Of DNA Repair U2-type Post-spliceosomal Complex DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Negative Regulation Of Mast Cell Chemotaxis Positive Regulation Of DNA Metabolic Process Zinc Ion Binding DNA Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Generation Of Catalytic Spliceosome For Second Transesterification Step Positive Regulation Of Telomere Maintenance ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity Phosphoglycolate Phosphatase Activity Positive Regulation Of Double-strand Break Repair Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation DNA Damage Response Regulation Of Protein Stability Positive Regulation Of Protein Localization To Nucleus Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity MRF Binding Response To Radiation Regulation Of Transcription By RNA Polymerase II Centriolar Satellite RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Purine Nucleotide Binding Double-stranded DNA Binding Positive Regulation Of Protein Localization To Nucleolus Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Response To UV Metal Ion Binding Regulation Of Protein Localization To Nucleus Lens Fiber Cell Morphogenesis Poly(G) Binding Telomerase Inhibitor Activity G-quadruplex RNA Binding Regulation Of Mast Cell Chemotaxis
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