PNKP and ZBTB14

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PNKP	ZBTB14
Gene Name		polynucleotide kinase 3-phosphatase	zinc finger and BTB domain containing 14
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	37 interactors: AP1M1 ATP5O BAZ2B BYSL CBX8 CDK16 CDKL3 CEP19 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 KAT5 MAD2L1BP MFAP1 MORF4L2 NAA10 PIN1 PNKP POLR2L PRMT1 RNPS1 RPL9 RPS7 SCNM1 SDCBP SNRPB2 SYT16 TCEANC TXN2 ZBTB21 ZCCHC10 ZMAT2
Entrez ID		11284	7541
HPRD ID		09284	03674
Ensembl ID		ENSG00000039650	ENSG00000198081
Uniprot IDs		Q96T60	B2R850 O43829
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process MRNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Viral Process Cellular Process Nuclear-transcribed MRNA Catabolic Process DNA Repair RNA Splicing MRNA Catabolic Process Protein Targeting To Membrane Ribosomal Small Subunit Biogenesis RNA Catabolic Process Biosynthetic Process Transcription, DNA-templated MRNA Processing Aromatic Compound Catabolic Process N-terminal Peptidyl-glutamic Acid Acetylation Polynucleotide 3' Dephosphorylation N-terminal Peptidyl-serine Acetylation NcRNA Metabolic Process Translational Initiation MRNA Splicing, Via Spliceosome Establishment Of Protein Localization To Membrane Establishment Of Localization In Cell RNA Splicing, Via Transesterification Reactions Dendrite Extension DNA-templated Transcription, Termination Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly
Tagcloud ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?