WBP4 and WDR83

Number of citations of the paper that reports this interaction (PubMedID 28838205)
63

Data Source:
BioGRID (two hybrid)

		WBP4	WDR83
Description		WW domain binding protein 4	WD repeat domain 83
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Spliceosomal Complex Cytoplasm Lysosome Endosome Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Response To Hypoxia Neural Tube Closure MRNA Processing RNA Splicing Response To Wounding Response To Lipopolysaccharide Regulation Of Canonical NF-kappaB Signal Transduction Placenta Blood Vessel Development Inflammatory Response To Wounding
Pathways		mRNA Splicing - Major Pathway	MAP2K and MAPK activation
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	36 interacting genes: BAG2 BCAS2 BCL6 CRB3 CRK CRYAA EGLN3 EXOSC1 FAM124B FRS3 GNE GPKOW GTSE1 HNRNPH2 HOXA1 HSPB1 KCTD9 KDM1A KEAP1 LONRF1 LSM3 NOXA1 PARD6A PARD6B PCBP2 PRKAB2 RACK1 SAP30BP SF1 SRSF8 TLX3 TOE1 VAC14 WBP4 ZC3H7A ZNF76
Entrez ID		11193	84292
HPRD ID		16086	14730
Ensembl ID		ENSG00000120688	ENSG00000123154
Uniprot IDs		O75554	Q9BRX9
PDB IDs		2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding	Nucleoplasm Nucleus Identical Protein Binding RNA Binding Nucleic Acid Binding Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Processing PAR Polarity Complex RNA Splicing, Via Transesterification Reactions RNA Splicing Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Binding Establishment Or Maintenance Of Apical/basal Cell Polarity MRNA Metabolic Process MRNA Processing Establishment Or Maintenance Of Cell Polarity RNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Precatalytic Spliceosome
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