WBP4 and EIF5B

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		WBP4	EIF5B
Description		WW domain binding protein 4	eukaryotic translation initiation factor 5B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding	TRNA Binding Nucleotide Binding RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		mRNA Splicing - Major Pathway	GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Bipolar disorder ( 21926972)
Interacting Genes		66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	14 interacting genes: BRCA1 CBL CDC42 CEBPA CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA SRSF12 TFCP2 WBP4 ZBTB3
Entrez ID		11193	9669
HPRD ID		16086	07304
Ensembl ID		ENSG00000120688	ENSG00000158417
Uniprot IDs		O75554	O60841 Q8N5A0
PDB IDs		2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS	7TQL 8PJ3 8PJ4 8PJ5
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding	Response To Ionizing Radiation Regulation Of Cell Cycle Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Endocytosis Response To Radiation Protein Tyrosine Kinase Binding RNA Metabolic Process Positive Regulation Of Cytokinesis Macrophage Differentiation Response To Peptide Response To Cytokine DNA Recombination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Protein Autoubiquitination BRCA1-BARD1 Complex GBD Domain Binding Storage Vacuole Cellular Response To Type II Interferon Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex MRNA Metabolic Process Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-12 BRCA1-B Complex Positive Regulation Of Metabolic Process DNA Damage Response Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Protein-containing Complex Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II
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