WBP4 and SART1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, pull down)

		WBP4	SART1
Description		WW domain binding protein 4	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding	RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Maturation Of 5S RRNA MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Cytotoxic T Cell Differentiation
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	16 interacting genes: APP CEBPA CHERP FILNC1 HSF2BP IGHE RNF10 SNW1 SRPK2 SRSF4 SUMO2 UBC UBE2I UBL5 WBP4 ZCCHC10
Entrez ID		11193	9092
HPRD ID		16086	10440
Ensembl ID		ENSG00000120688	ENSG00000175467
Uniprot IDs		O75554	O43290
PDB IDs		2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS	4PYU 5O9Z 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding	Protein Tag Activity Macromolecule Metabolic Process MRNA Processing RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing Regulation Of MRNA Splicing, Via Spliceosome SUMO Transferase Activity RNA Metabolic Process MRNA Metabolic Process Nucleoplasm Regulation Of MRNA Processing Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteolysis Protein Modification Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding IgE B Cell Receptor Complex Nuclear Speck Regulation Of RNA Splicing SUMO Conjugating Enzyme Activity MRNA Splicing, Via Spliceosome Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Sumoylation Positive Regulation Of Calcium-mediated Signaling Presynapse Acetylcholine Receptor Activator Activity Macrophage Activation Antibacterial Humoral Response Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Acute Inflammatory Response Nucleic Acid Metabolic Process Primary Adaptive Immune Response B Cell Antigen Processing And Presentation Type I Hypersensitivity Glutamatergic Synapse Nucleic Acid Binding Positive Regulation Of Neuron Apoptotic Process PTB Domain Binding
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