WBP4 and ARGLU1

Number of citations of the paper that reports this interaction (PubMedID 28838205)
63

Data Source:
BioGRID (two hybrid)

		WBP4	ARGLU1
Description		WW domain binding protein 4	arginine and glutamate rich 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Chromosome Mitochondrion Cytosol Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding	Transcription Coactivator Activity RNA Binding Protein Binding Pre-mRNA Binding Cadherin Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Abstraction and mental flexibility ( 31596458) Chronotype ( 30696823) Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
Interacting Genes		66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	9 interacting genes: APP CHERP IKBKG PRMT5 RUNX1 SRPK1 SRPK2 WBP4 ZCCHC10
Entrez ID		11193	55082
HPRD ID		16086	07648
Ensembl ID		ENSG00000120688	ENSG00000134884
Uniprot IDs		O75554	Q9NWB6
PDB IDs		2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding	Protein Heterodimerization Activity Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing Protein-RNA Complex Assembly Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein-containing Complex Assembly Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Defense Response To Symbiont Protein-containing Complex Organization Defense Response To Other Organism Positive Regulation Of Neuron Apoptotic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Chromatin Organization RNA Splicing RNA Processing Acetylcholine Receptor Activator Activity Regulation Of Proteolysis Lipoprotein Particle Positive Regulation Of Protein Import Peptidyl-arginine N-methylation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Core-binding Factor Complex Nuclear Speck MRNA Processing
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