WDR83 and LONRF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WDR83	LONRF1
Description		WD repeat domain 83	LON peptidase N-terminal domain and ring finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Lysosome Endosome Membrane Catalytic Step 2 Spliceosome	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Response To Hypoxia Neural Tube Closure MRNA Processing RNA Splicing Response To Wounding Response To Lipopolysaccharide Regulation Of Canonical NF-kappaB Signal Transduction Placenta Blood Vessel Development Inflammatory Response To Wounding
Pathways		MAP2K and MAPK activation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Colorectal cancer (diet interaction) ( 24743840) HDL cholesterol levels ( 32203549)
Interacting Genes		36 interacting genes: BAG2 BCAS2 BCL6 CRB3 CRK CRYAA EGLN3 EXOSC1 FAM124B FRS3 GNE GPKOW GTSE1 HNRNPH2 HOXA1 HSPB1 KCTD9 KDM1A KEAP1 LONRF1 LSM3 NOXA1 PARD6A PARD6B PCBP2 PRKAB2 RACK1 SAP30BP SF1 SRSF8 TLX3 TOE1 VAC14 WBP4 ZC3H7A ZNF76	98 interacting genes: ADAMTSL4 ALAS1 AP2B1 ATG9A AVPI1 BRCA1 BYSL C4orf17 CALCOCO2 CBLL2 CDKN2D CFP CRX CYSRT1 DSCR9 DVL3 EFHC2 FLACC1 GABPB2 GORASP1 GORASP2 GPRASP3 HLX HOXA1 HSPB1 IHO1 IKZF2 IKZF3 IQCF2 KAT5 KATNBL1 KCTD21 KCTD9 KHDC1 KRT31 KRT35 KRT75 KRTAP1-3 KRTAP13-1 KRTAP13-3 KRTAP19-6 KRTAP19-7 KRTAP3-3 KRTAP6-1 LGALS9B LHX2 LHX4 LNX1 MAGED1 MGAT5B MID2 MRPL38 MTMR3 MYOZ3 NR4A1 NTAQ1 OOEP PATZ1 PAX5 PAX6 PAX8 PICK1 PLSCR1 POU6F2 PPP1R3C PRDM16 PRDM6 PRR35 PSMA1 RBPMS RIMBP3C RPRD1A RSPH1 SFN SLU7 SPRY2 STAU1 STX11 TASOR2 TBX19 TRAF2 TRIM27 TRIM42 TRIM8 TRIM9 UBE2I UBE2L6 UCHL3 USP2 VGLL1 WDR83 XIAP YPEL3 ZFP90 ZNF426 ZNF653 ZNF774 ZNHIT2
Entrez ID		84292	91694
HPRD ID		14730	08674
Ensembl ID		ENSG00000123154	ENSG00000154359
Uniprot IDs		Q9BRX9	Q17RB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Identical Protein Binding RNA Binding Nucleic Acid Binding Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Processing PAR Polarity Complex RNA Splicing, Via Transesterification Reactions RNA Splicing Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Binding Establishment Or Maintenance Of Apical/basal Cell Polarity MRNA Metabolic Process MRNA Processing Establishment Or Maintenance Of Cell Polarity RNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Precatalytic Spliceosome	Intermediate Filament Protein Binding Zinc Ion Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Keratin Filament Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of DNA-templated Transcription Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Protein Kinase C Inhibitor Activity Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Positive Regulation Of Biosynthetic Process Regulation Of Viral Transcription Regulation Of RNA Metabolic Process Protein Modification Process Establishment Of Spindle Localization Structural Constituent Of Skin Epidermis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Spindle Localization Non-canonical Inflammasome Complex Assembly Telencephalon Regionalization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Outer Dense Fiber Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Cytosol Protein K63-linked Ubiquitination Negative Regulation Of Viral Process Positive Regulation Of Macromolecule Metabolic Process Nucleus
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