WDR83 and PCBP2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		WDR83	PCBP2
Gene Name		WD repeat domain 83	poly(rC) binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex Cytoplasm Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	DNA Binding RNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression MRNA Metabolic Process Negative Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Negative regulators of RIG-I/MDA5 signaling mRNA Splicing - Major Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AQR BAG2 CRB3 EGLN3 GNB2L1 GPKOW HNRNPH2 HSPB1 KDM1A KEAP1 LSM3 PARD6A PARD6B PCBP2 SAP30BP SF1 TOE1	25 interactors: BARD1 CASK CNBP FLNA HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL NKAP PABPC1 PAXIP1 PCBP1 PRPF40A PTBP1 QKI SF3B2 SLU7 SNRPA SRSF3 SRSF7 WDR77 WDR83 YBX1 YBX3
Entrez ID		84292	5094
HPRD ID		14730	03129
Ensembl ID		ENSG00000123154	ENSG00000197111
Uniprot IDs		Q9BRX9	B4DXP5 F8VZX2 G3V0E8 Q15366
PDB IDs			2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Tight Junction Assembly MRNA Processing Apical Junction Assembly MRNA Metabolic Process RNA Processing Cell-cell Junction Assembly Gene Expression Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cellular Response To Oxidative Stress RNA Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of CAMP Catabolic Process Heterocycle Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Zymogen Activation Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Primary Sex Determination Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Embryonic Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway MRNA 3'-splice Site Recognition Positive Regulation Of Endopeptidase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Female Gonad Development Nitrogen Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Peptidase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone H3-K4 Methylation	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Oncogene-induced Cell Senescence Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of MRNA Processing MRNA Stabilization Regulation Of Nitrogen Compound Metabolic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Gene Expression Positive Regulation Of Cellular Senescence Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Aging Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translation Heterochromatin Assembly Biosynthetic Process MRNA 3'-end Processing Heterochromatin Organization Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Translation
Tagcloud ?			9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
Tagcloud (Difference) ?			9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
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