WBP4 and HTATSF1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		WBP4	HTATSF1
Description		WW domain binding protein 4	HIV-1 Tat specific factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Chromosome Site Of Double-strand Break
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding	Nucleic Acid Binding RNA Binding Protein Binding Chromatin-protein Adaptor Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization MRNA Processing DNA Damage Response RNA Splicing U2-type Prespliceosome Assembly Protein Localization To Site Of Double-strand Break
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	21 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 MAP1LC3A POLR2A RNF10 SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H WBP4 ZNF512B
Entrez ID		11193	27336
HPRD ID		16086	02282
Ensembl ID		ENSG00000120688	ENSG00000102241
Uniprot IDs		O75554	O43719
PDB IDs		2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q 7EVO 7Q3L 8HK1
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding	RNA Metabolic Process DNA-templated Transcription Elongation Nucleic Acid Metabolic Process Transcription Elongation By RNA Polymerase II Nucleoplasm Positive Regulation Of DNA-templated Transcription, Elongation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Nuclear Speck Regulation Of Gene Expression P-TEFb Complex DSIF Complex Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription, Elongation RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Metabolic Process DNA-templated Transcription MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of MRNA Processing Transcription By RNA Polymerase II Spliceosomal Complex Assembly Transcription Elongation-coupled Chromatin Remodeling U2-type Precatalytic Spliceosome Negative Regulation Of Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex U1 SnRNA Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II 7SK SnRNA Binding Nucleic Acid Binding Positive Regulation Of Metabolic Process Spliceosomal Complex Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Autophagy Positive Regulation Of Transcription By RNA Polymerase II SnRNA Binding
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